{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:19:56Z","timestamp":1792667996274,"version":"4.5.0"},"reference-count":49,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,11,7]]},"abstract":"<jats:p>We showed previously that NKT cell\u2013deficient TCR J\u03b118\u2212\/\u2212 mice are more susceptible to methylcholanthrene (MCA)-induced sarcomas, and that normal tumor surveillance can be restored by adoptive transfer of WT liver-derived NKT cells. Liver-derived NKT cells were used in these studies because of their relative abundance in this organ, and it was assumed that they were representative of NKT cells from other sites. We compared NKT cells from liver, thymus, and spleen for their ability to mediate rejection of the sarcoma cell line (MCA-1) in vivo, and found that this was a specialized function of liver-derived NKT cells. Furthermore, when CD4+ and CD4\u2212 liver-derived NKT cells were administered separately, MCA-1 rejection was mediated primarily by the CD4\u2212 fraction. Very similar results were achieved using the B16F10 melanoma metastasis model, which requires NKT cell stimulation with \u03b1-galactosylceramide. The impaired ability of thymus-derived NKT cells was due, in part, to their production of IL-4, because tumor immunity was clearly enhanced after transfer of IL-4\u2013deficient thymus-derived NKT cells. This is the first study to demonstrate the existence of functionally distinct NKT cell subsets in vivo and may shed light on the long-appreciated paradox that NKT cells function as immunosuppressive cells in some disease models, whereas they promote cell-mediated immunity in others.<\/jats:p>","DOI":"10.1084\/jem.20050953","type":"journal-article","created":{"date-parts":[[2005,11,7]],"date-time":"2005-11-07T20:03:02Z","timestamp":1131393782000},"page":"1279-1288","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":314,"title":["Differential antitumor immunity mediated by NKT cell subsets in vivo"],"prefix":"10.1084","volume":"202","author":[{"given":"Nadine Y.","family":"Crowe","sequence":"first","affiliation":[{"name":"1Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Coquet","sequence":"additional","affiliation":[{"name":"1Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart P.","family":"Berzins","sequence":"additional","affiliation":[{"name":"1Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kyparissoudis","sequence":"additional","affiliation":[{"name":"1Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Keating","sequence":"additional","affiliation":[{"name":"1Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Pellicci","sequence":"additional","affiliation":[{"name":"1Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"2Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale I.","family":"Godfrey","sequence":"additional","affiliation":[{"name":"1Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Smyth","sequence":"additional","affiliation":[{"name":"2Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,11,7]]},"reference":[{"key":"2023072513233780500_BIB1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri1309","volume":"4","year":"2004","journal-title":"Nat. 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