{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:19:49Z","timestamp":1791328789278,"version":"4.3.1"},"reference-count":53,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,2,20]]},"abstract":"<jats:p>Wild-type (WT) NOD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) when given 0.05% NaI in their drinking water, whereas B cell\u2013deficient NOD.H-2h4 mice are SAT resistant. To test the hypothesis that resistance of B cell\u2013deficient mice to SAT was due to the activity of regulatory CD4+CD25+ T (T reg) cells activated if autoantigen was initially presented on non\u2013B cells, CD25+ T reg cells were transiently depleted in vivo using anti-CD25. B cell\u2013deficient NOD.H-2h4 mice given three weekly injections of anti-CD25 developed SAT 8 wk after NaI water. Thyroid lesions were similar to those in WT mice except there were no B cells in thyroid infiltrates. WT and B cell\u2013deficient mice had similar numbers of CD4+CD25+Foxp3+ cells. Mice with transgenic nitrophenyl-specific B cells unable to secrete immunoglobulin were also resistant to SAT, and transient depletion of T reg cells resulted in severe SAT with both T and B cells in thyroid infiltrates. T reg cells that inhibit SAT were eliminated by day 3 thymectomy, indicating they belong to the subset of naturally occurring T reg cells. However, T reg cell depletion did not increase SAT severity in WT mice, suggesting that T reg cells may be nonfunctional when effector T cells are activated; i.e., by autoantigen-presenting B cells.<\/jats:p>","DOI":"10.1084\/jem.20051438","type":"journal-article","created":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T20:49:01Z","timestamp":1138654141000},"page":"349-358","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["B cell\u2013deficient NOD.H-2h4 mice have CD4+CD25+ T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis"],"prefix":"10.1084","volume":"203","author":[{"given":"Shiguang","family":"Yu","sequence":"first","affiliation":[{"name":"1Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanta K.","family":"Maiti","sequence":"additional","affiliation":[{"name":"1Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Dyson","sequence":"additional","affiliation":[{"name":"3Department of Veterinary Pathobiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Jain","sequence":"additional","affiliation":[{"name":"2Department of Molecular Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Braley-Mullen","sequence":"additional","affiliation":[{"name":"1Department of Medicine"},{"name":"2Department of Molecular Microbiology and Immunology"},{"name":"4VA Research Service, University of Missouri, Columbia, MO 65212"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2006,1,30]]},"reference":[{"key":"2023072513471858300_BIB1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/jaut.1999.0272","volume":"12","year":"1999","journal-title":"J. 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