{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:20:50Z","timestamp":1793042450773,"version":"4.5.0"},"reference-count":30,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,4,17]]},"abstract":"<jats:p>The cytokine interleukin (IL) 25 has been implicated in the initiation of type 2 immunity by driving the expression of type 2 cytokines such as IL-5 and IL-13, although its role in the regulation of immunity and infection-induced inflammation is unknown. Here, we identify a dual function for IL-25: first, in promoting type 2 cytokine-dependent immunity to gastrointestinal helminth infection and, second, in limiting proinflammatory cytokine production and chronic intestinal inflammation. Treatment of genetically susceptible mice with exogenous IL-25 promoted type 2 cytokine responses and immunity to Trichuris. IL-25 was constitutively expressed by CD4+ and CD8+ T cells in the gut of mouse strains that are resistant to Trichuris, and IL-25\u2013deficient mice on a genetically resistant background failed to develop a type 2 immune response or eradicate infection. Furthermore, chronically infected IL-25\u2212\/\u2212 mice developed severe infection-induced intestinal inflammation associated with heightened expression of interferon-\u03b3 and IL-17, identifying a role for IL-25 in limiting pathologic inflammation at mucosal sites. Therefore, IL-25 is not only a critical mediator of type 2 immunity, but is also required for the regulation of inflammation in the gastrointestinal tract.<\/jats:p>","DOI":"10.1084\/jem.20051496","type":"journal-article","created":{"date-parts":[[2006,4,10]],"date-time":"2006-04-10T20:33:39Z","timestamp":1144701219000},"page":"843-849","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":332,"title":["Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract"],"prefix":"10.1084","volume":"203","author":[{"given":"Alexander M.","family":"Owyang","sequence":"first","affiliation":[{"name":"2Discovery Research, Schering-Plough Biopharma, Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colby","family":"Zaph","sequence":"additional","affiliation":[{"name":"1Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma H.","family":"Wilson","sequence":"additional","affiliation":[{"name":"1Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Guild","sequence":"additional","affiliation":[{"name":"1Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrill","family":"McClanahan","sequence":"additional","affiliation":[{"name":"2Discovery Research, Schering-Plough Biopharma, Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh R. 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