{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:33:46Z","timestamp":1791401626509,"version":"4.3.3"},"reference-count":40,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,12,5]]},"abstract":"<jats:p>The role of natural CD4+CD25+ regulatory T (T reg) cells in the control of allergic asthma remains poorly understood. We explore the impact of T reg cell depletion on the allergic response in mice susceptible (A\/J) or comparatively resistant (C3H) to the development of allergen-induced airway hyperresponsiveness (AHR). In C3H mice, anti-CD25\u2013mediated T reg cell depletion before house dust mite treatment increased several features of the allergic diathesis (AHR, eosinophilia, and IgE), which was concomitant with elevated T helper type 2 (Th2) cytokine production. In similarly T reg cell\u2013depleted A\/J mice, we observed a moderate increase in airway eosinophilia but no effects on AHR, IgE levels, or Th2 cytokine synthesis. As our experiments suggested that T reg cell depletion in C3H mice before sensitization was sufficient to enhance the allergic phenotype, we characterized dendritic cells (DCs) in T reg cell\u2013depleted C3H mice. T reg cell\u2013depleted mice had increased numbers of pulmonary myeloid DCs with elevated expression of major histocompatibility complex class II, CD80, and CD86. Moreover, DCs from T reg cell\u2013depleted mice demonstrated an increased capacity to stimulate T cell proliferation and Th2 cytokine production, which was concomitant with reduced IL-12 expression. These data suggest that resistance to allergen-driven AHR is mediated in part by CD4+CD25+ T reg cell suppression of DC activation and that the absence of this regulatory pathway contributes to susceptibility.<\/jats:p>","DOI":"10.1084\/jem.20051506","type":"journal-article","created":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T20:25:29Z","timestamp":1133209529000},"page":"1549-1561","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":327,"title":["CD4\n                    <b>+<\/b>\n                    CD25\n                    <b>+<\/b>\n                    T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function"],"prefix":"10.1084","volume":"202","author":[{"given":"Ian P.","family":"Lewkowich","sequence":"first","affiliation":[{"name":"1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy S.","family":"Herman","sequence":"additional","affiliation":[{"name":"1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen W.","family":"Schleifer","sequence":"additional","affiliation":[{"name":"1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Dance","sequence":"additional","affiliation":[{"name":"1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Chen","sequence":"additional","affiliation":[{"name":"1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista M.","family":"Dienger","sequence":"additional","affiliation":[{"name":"1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa A.","family":"Sproles","sequence":"additional","affiliation":[{"name":"1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimin S.","family":"Shah","sequence":"additional","affiliation":[{"name":"1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0308rg","family":"Ko\u0308hl","sequence":"additional","affiliation":[{"name":"2Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Belkaid","sequence":"additional","affiliation":[{"name":"2Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha","family":"Wills-Karp","sequence":"additional","affiliation":[{"name":"1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,11,28]]},"reference":[{"key":"2023072513054130000_BIB1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.0105-2896.2004.00215.x","volume":"202","year":"2004","journal-title":"Immunol. 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