{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:27:02Z","timestamp":1792178822431,"version":"4.4.0"},"reference-count":23,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,8,7]]},"abstract":"<jats:p>Members of the \u03b1- and \u03b2-subfamily of herpesviridae encode glycoproteins that specifically bind to the Fc part of immunoglobulin (Ig)G. Plasma membrane resident herpesviral Fc receptors seem to prevent virus-specific IgG from activating antibody-dependent effector functions. We show that the mouse cytomegalovirus (MCMV) molecule fcr-1 promotes a rapid down-regulation of NKG2D ligands murine UL16-binding protein like transcript (MULT)-1 and H60 from the cell surface. Deletion of the m138\/fcr-1 gene from the MCMV genome attenuates viral replication to natural killer (NK) cell response in an NKG2D-dependent manner in vivo. A distinct N-terminal module within the fcr-1 ectodomain in conjunction with the fcr-1 transmembrane domain was required to dispose MULT-1 to degradation in lysosomes. In contrast, down-modulation of H60 required the complete fcr-1 ectodomain, implying independent modes of fcr-1 interaction with the NKG2D ligands. The results establish a novel viral strategy for down-modulating NK cell responses and highlight the impressive diversity of Fc receptor functions.<\/jats:p>","DOI":"10.1084\/jem.20060514","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T20:25:38Z","timestamp":1152563138000},"page":"1843-1850","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60"],"prefix":"10.1084","volume":"203","author":[{"given":"Tihana","family":"Lenac","sequence":"first","affiliation":[{"name":"1Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Budt","sequence":"additional","affiliation":[{"name":"2Institute for Virology, Heinrich-Heine-University Du\u0308sseldorf, 40225 Du\u0308sseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurica","family":"Arapovic","sequence":"additional","affiliation":[{"name":"1Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Hasan","sequence":"additional","affiliation":[{"name":"1Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"2Institute for Virology, Heinrich-Heine-University Du\u0308sseldorf, 40225 Du\u0308sseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrvoje","family":"Simic","sequence":"additional","affiliation":[{"name":"1Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Krmpotic","sequence":"additional","affiliation":[{"name":"1Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Messerle","sequence":"additional","affiliation":[{"name":"3Institute for Virology, Hannover Medical School, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Ruzsics","sequence":"additional","affiliation":[{"name":"4Max von Pettenkofer Institute, Ludwig Maximilians University of Munich, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich H.","family":"Koszinowski","sequence":"additional","affiliation":[{"name":"4Max von Pettenkofer Institute, Ludwig Maximilians University of Munich, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Hengel","sequence":"additional","affiliation":[{"name":"2Institute for Virology, Heinrich-Heine-University Du\u0308sseldorf, 40225 Du\u0308sseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stipan","family":"Jonjic","sequence":"additional","affiliation":[{"name":"1Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2006,7,10]]},"reference":[{"key":"2023072515131534100_BIB1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S095279150200002X","volume":"15","year":"2003","journal-title":"Curr. 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