{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:22:53Z","timestamp":1791300173944,"version":"4.1.0"},"reference-count":52,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,10,2]]},"abstract":"<jats:p>In this study, we demonstrate that the in vitro interactions between a CD56neg\/CD16pos (CD56neg) subset of natural killer (NK) cells and autologous dendritic cells (DCs) from HIV-1\u2013infected viremic but not aviremic individuals are markedly impaired and likely interfere with the development of an effective immune response. Among the defective interactions are abnormalities in the process of reciprocal NK\u2013DC activation and maturation as well as a defect in the NK cell\u2013mediated editing or elimination of immature DCs (iDCs). Notably, the lysis of mature DCs (mDCs) by autologous NK cells was highly impaired even after the complete masking of major histocompatibility complex I molecules, suggesting that the defective elimination of autologous iDCs is at the level of activating NK cell receptors. In this regard, the markedly impaired expression\/secretion and function of NKp30 and TNF-related apoptosis-inducing ligand, particularly among the CD56neg NK cell subset, largely accounts for the highly defective NK cell\u2013mediated lysis of autologous iDCs. Moreover, mDCs generated from HIV-1 viremic but not aviremic patients are substantially impaired in their ability to secrete interleukin (IL)-10 and -12 and to prime the proliferation of neighboring autologous NK cells, which, in turn, fail to secrete adequate amounts of interferon-\u03b3.<\/jats:p>","DOI":"10.1084\/jem.20060894","type":"journal-article","created":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T00:59:01Z","timestamp":1159232341000},"page":"2339-2350","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":163,"title":["Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection"],"prefix":"10.1084","volume":"203","author":[{"given":"Domenico","family":"Mavilio","sequence":"first","affiliation":[{"name":"1Laboratory of Immunoregulation"},{"name":"3Dipartimento di Medicina Sperimentale, University of Genova, Genova 16132, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Lombardo","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Kinter","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Fogli","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"La Sala","sequence":"additional","affiliation":[{"name":"4Istituto San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico, Rome 00163, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saida","family":"Ortolano","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annahita","family":"Farschi","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Follmann","sequence":"additional","affiliation":[{"name":"2Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roby","family":"Gregg","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Kovacs","sequence":"additional","affiliation":[{"name":"5Department of Medicine, University of Toronto, Toronto M5S 1A1, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Marcenaro","sequence":"additional","affiliation":[{"name":"3Dipartimento di Medicina Sperimentale, University of Genova, Genova 16132, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pende","sequence":"additional","affiliation":[{"name":"6Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Moretta","sequence":"additional","affiliation":[{"name":"3Dipartimento di Medicina Sperimentale, University of Genova, Genova 16132, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Fauci","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2006,9,25]]},"reference":[{"key":"2023072513232878300_BIB1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nri956","volume":"2","year":"2002","journal-title":"Nat. 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