{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:56:54Z","timestamp":1791356214670,"version":"4.3.1"},"reference-count":61,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,10,30]]},"abstract":"<jats:p>A defining characteristic of persistent viral infections is the loss and functional inactivation of antiviral effector T cells, which prevents viral clearance. Interleukin-10 (IL-10) suppresses cellular immune responses by modulating the function of T cells and antigen-presenting cells. In this paper, we report that IL-10 production is drastically increased in mice persistently infected with lymphocytic choriomeningitis virus. In vivo blockade of the IL-10 receptor (IL-10R) with a neutralizing antibody resulted in rapid resolution of the persistent infection. IL-10 secretion was diminished and interferon \u03b3 production by antiviral CD8+ T cells was enhanced. In persistently infected mice, CD8\u03b1+ dendritic cell (DC) numbers declined early after infection, whereas CD8\u03b1\u2212 DC numbers were not affected. CD8\u03b1\u2212 DCs supported IL-10 production and subsequent dampening of antiviral T cell responses. Therapeutic IL-10R blockade broke the cycle of IL-10\u2013mediated immune suppression, preventing IL-10 priming by CD8\u03b1\u2212 DCs and enhancing antiviral responses and thereby resolving infection without causing immunopathology.<\/jats:p>","DOI":"10.1084\/jem.20061462","type":"journal-article","created":{"date-parts":[[2006,10,9]],"date-time":"2006-10-09T21:03:27Z","timestamp":1160427807000},"page":"2461-2472","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":476,"title":["Resolution of a chronic viral infection after interleukin-10 receptor blockade"],"prefix":"10.1084","volume":"203","author":[{"given":"Mette","family":"Ejrnaes","sequence":"first","affiliation":[{"name":"1Immune Regulation Lab \u2013 DI3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe M.","family":"Filippi","sequence":"additional","affiliation":[{"name":"1Immune Regulation Lab \u2013 DI3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne M.","family":"Martinic","sequence":"additional","affiliation":[{"name":"1Immune Regulation Lab \u2013 DI3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor M.","family":"Ling","sequence":"additional","affiliation":[{"name":"1Immune Regulation Lab \u2013 DI3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Togher","sequence":"additional","affiliation":[{"name":"1Immune Regulation Lab \u2013 DI3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Crotty","sequence":"additional","affiliation":[{"name":"2Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias G.","family":"von Herrath","sequence":"additional","affiliation":[{"name":"1Immune Regulation Lab \u2013 DI3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2006,10,9]]},"reference":[{"key":"2023072513300133800_BIB1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.iy.11.040193.001121","volume":"11","year":"1993","journal-title":"Annu. 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