{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:42:51Z","timestamp":1793385771289,"version":"4.5.0"},"reference-count":52,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,11,27]]},"abstract":"<jats:p>In autoimmune arthritis, traditionally classified as a T helper (Th) type 1 disease, the activation of T cells results in bone destruction mediated by osteoclasts, but how T cells enhance osteoclastogenesis despite the anti-osteoclastogenic effect of interferon (IFN)-\u03b3 remains to be elucidated. Here, we examine the effect of various Th cell subsets on osteoclastogenesis and identify Th17, a specialized inflammatory subset, as an osteoclastogenic Th cell subset that links T cell activation and bone resorption. The interleukin (IL)-23\u2013IL-17 axis, rather than the IL-12\u2013IFN-\u03b3 axis, is critical not only for the onset phase, but also for the bone destruction phase of autoimmune arthritis. Thus, Th17 is a powerful therapeutic target for the bone destruction associated with T cell activation.<\/jats:p>","DOI":"10.1084\/jem.20061775","type":"journal-article","created":{"date-parts":[[2006,11,6]],"date-time":"2006-11-06T20:44:19Z","timestamp":1162845859000},"page":"2673-2682","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1375,"title":["Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction"],"prefix":"10.1084","volume":"203","author":[{"given":"Kojiro","family":"Sato","sequence":"first","affiliation":[{"name":"1Department of Cell Signaling,"},{"name":"3COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113-8549, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Suematsu","sequence":"additional","affiliation":[{"name":"1Department of Cell Signaling,"},{"name":"3COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113-8549, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Okamoto","sequence":"additional","affiliation":[{"name":"1Department of Cell Signaling,"},{"name":"3COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113-8549, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"2Department of Oral Pathology, Graduate School, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Morishita","sequence":"additional","affiliation":[{"name":"4Department of Human Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuho","family":"Kadono","sequence":"additional","affiliation":[{"name":"5Department of Orthopaedic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakae","family":"Tanaka","sequence":"additional","affiliation":[{"name":"5Department of Orthopaedic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiko","family":"Kodama","sequence":"additional","affiliation":[{"name":"6Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuo","family":"Akira","sequence":"additional","affiliation":[{"name":"7Department of Host Defence, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"8Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Cua","sequence":"additional","affiliation":[{"name":"9Discovery Research, DNAX Research Inc., Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takayanagi","sequence":"additional","affiliation":[{"name":"1Department of Cell Signaling,"},{"name":"3COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113-8549, Japan"},{"name":"10Solution Oriented Research for Science and Technology (SORST), Japan Science and Technology Agency (JST), Saitama 332-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2006,11,6]]},"reference":[{"key":"2023072515191578300_BIB1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.immunol.24.021605.090646","volume":"24","year":"2006","journal-title":"Annu. 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