{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:28:52Z","timestamp":1792740532005,"version":"4.5.0"},"reference-count":28,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,3,19]]},"abstract":"<jats:p>Interleukin (IL) 31R\u03b1 (glycoprotein 130\u2013like monocyte receptor and glycoprotein 130\u2013like receptor) heterodimerizes with oncostatin M receptor \u03b2 to bind IL-31, a cytokine expressed preferentially by CD4+ T helper type 2 (Th2) cells. However, the functions of IL-31\u2013IL-31R signaling in immune regulation remain unknown. Here, we identify a novel role for IL-31R in limiting type 2 inflammation in the lung. After intravenous injection of Schistosoma mansoni eggs, IL-31R\u03b1\u2212\/\u2212 mice developed severe pulmonary inflammation, characterized by an increase in the area of granulomatous inflammation, increased numbers of resistin-like molecule \u03b1+ cells, and enhanced collagen deposition compared to WT counterparts. In vitro, macrophages generated from IL-31R\u03b1\u2212\/\u2212 mice promoted enhanced ovalbumin-specific CD4+ T cell proliferation and purified naive CD4+ T cells from IL-31R\u03b1\u2212\/\u2212 mice exhibited enhanced proliferation and expression of Th2 cytokines, identifying a T cell\u2013 and macrophage-intrinsic regulatory function for IL-31R signaling. In contrast, the generation of CD4+ T cell\u2013mediated Th1 responses were normal in IL-31R\u03b1\u2212\/\u2212 mice, suggesting that the regulatory role of IL-31R signaling is limited to type 2 responses. Together, these data implicate IL-31R signaling as a novel negative regulatory pathway that specifically limits type 2 inflammation.<\/jats:p>","DOI":"10.1084\/jem.20061791","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T01:23:44Z","timestamp":1173749024000},"page":"481-487","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["IL-31\u2013IL-31R interactions negatively regulate type 2 inflammation in the lung"],"prefix":"10.1084","volume":"204","author":[{"given":"Jacqueline G.","family":"Perrigoue","sequence":"first","affiliation":[{"name":"1Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"2Genentech, Inc., South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colby","family":"Zaph","sequence":"additional","affiliation":[{"name":"1Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"1Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Scott","sequence":"additional","affiliation":[{"name":"1Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic J.","family":"de Sauvage","sequence":"additional","affiliation":[{"name":"2Genentech, Inc., South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Pearce","sequence":"additional","affiliation":[{"name":"1Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Ghilardi","sequence":"additional","affiliation":[{"name":"2Genentech, Inc., South San Francisco, CA 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Artis","sequence":"additional","affiliation":[{"name":"1Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,3,12]]},"reference":[{"key":"2023072516134799000_BIB1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1074-7613(03)00211-5","volume":"19","year":"2003","journal-title":"Immunity."},{"key":"2023072516134799000_BIB2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00130832-200212000-00004","volume":"2","year":"2002","journal-title":"Curr. 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