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Synergy between the innate and adaptive responses was also shown when TLR2\u2212\/\u2212 mice exhibited impaired intraabdominal abscess formation in response to B. fragilis. Commensal bacteria, using molecules like PSA, potentially modulate the Th1\/Th2 cell balance and the response to infection by coordinating both the innate and adaptive pathways.<\/jats:p>","DOI":"10.1084\/jem.20062008","type":"journal-article","created":{"date-parts":[[2006,12,19]],"date-time":"2006-12-19T01:34:45Z","timestamp":1166492085000},"page":"2853-2863","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":258,"title":["A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2"],"prefix":"10.1084","volume":"203","author":[{"given":"Qun","family":"Wang","sequence":"first","affiliation":[{"name":"1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115"},{"name":"2Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"McLoughlin","sequence":"additional","affiliation":[{"name":"1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Cobb","sequence":"additional","affiliation":[{"name":"1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115"},{"name":"2Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Charrel-Dennis","sequence":"additional","affiliation":[{"name":"1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115"},{"name":"2Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen J.","family":"Zaleski","sequence":"additional","affiliation":[{"name":"1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Golenbock","sequence":"additional","affiliation":[{"name":"3Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur O.","family":"Tzianabos","sequence":"additional","affiliation":[{"name":"1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis L.","family":"Kasper","sequence":"additional","affiliation":[{"name":"1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115"},{"name":"2Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2006,12,18]]},"reference":[{"key":"2023072515172667200_BIB1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/35107092","volume":"414","year":"2001","journal-title":"Nature."},{"key":"2023072515172667200_BIB2","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1126\/science.8211161","volume":"262","year":"1993","journal-title":"Science."},{"key":"2023072515172667200_BIB3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2005.05.007","volume":"122","year":"2005","journal-title":"Cell."},{"key":"2023072515172667200_BIB4","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/j.carres.2003.06.005","volume":"338","year":"2003","journal-title":"Carbohydr. 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