{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:24:28Z","timestamp":1791181468996,"version":"4.1.0"},"reference-count":51,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,3,19]]},"abstract":"<jats:p>To elucidate the mechanisms underlying chromosomal translocations in diffuse large B cell lymphoma (DLBCL), we investigated the nature and extent of immunoglobulin class switch recombination (CSR) in these tumors. We used Southern blotting to detect legitimate and illegitimate CSR events in tumor samples of the activated B cell\u2013like (ABC), germinal center B cell\u2013like (GCB), and primary mediastinal B cell lymphoma (PMBL) subgroups of DLBCL. The frequency of legitimate CSR was lower in ABC DLBCL than in GCB DLBCL and PMBL. In contrast, ABC DLBCL had a higher frequency of internal deletions within the switch \u03bc (S\u03bc) region compared with GCB DLBCL and PMBL. ABC DLBCLs also had frequent deletions within S\u03b3 and other illegitimate switch recombinations. Sequence analysis revealed ongoing S\u03bc deletions within ABC DLBCL tumor clones, which were accompanied by ongoing duplications and activation-induced cytidine deaminase\u2013dependent somatic mutations. Unexpectedly, short fragments derived from multiple chromosomes were interspersed within S\u03bc in one case. These findings suggest that ABC DLBCLs have abnormalities in the regulation of CSR that could predispose to chromosomal translocations. Accordingly, aberrant switch recombination was responsible for translocations in ABC DLBCLs involving BCL6, MYC, and a novel translocation partner, SPIB.<\/jats:p>","DOI":"10.1084\/jem.20062041","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T05:23:44Z","timestamp":1173763424000},"page":"633-643","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":182,"title":["Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell\u2013like diffuse large B cell lymphoma"],"prefix":"10.1084","volume":"204","author":[{"given":"Georg","family":"Lenz","sequence":"first","affiliation":[{"name":"1Metabolism Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Nagel","sequence":"additional","affiliation":[{"name":"5Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel, D-24105 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[{"name":"5Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel, D-24105 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Roschke","sequence":"additional","affiliation":[{"name":"3Genetics Branch, Center for Cancer Research,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Sanger","sequence":"additional","affiliation":[{"name":"6Department of Pathology and Department of Microbiology, University of Nebraska Medical Center, Omaha, NE 68198"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Wright","sequence":"additional","affiliation":[{"name":"4Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep S.","family":"Dave","sequence":"additional","affiliation":[{"name":"1Metabolism Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Tan","sequence":"additional","affiliation":[{"name":"1Metabolism Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"1Metabolism Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rosenwald","sequence":"additional","affiliation":[{"name":"7Department of Pathology, University of Wu\u0308rzburg, 97070 Wu\u0308rzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Konrad","family":"Muller-Hermelink","sequence":"additional","affiliation":[{"name":"7Department of Pathology, University of Wu\u0308rzburg, 97070 Wu\u0308rzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy D.","family":"Gascoyne","sequence":"additional","affiliation":[{"name":"8British Columbia Cancer Agency, Vancouver, British Columbia V5Z 4E6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Campo","sequence":"additional","affiliation":[{"name":"9Hospital Clinic, University of Barcelona, 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine S.","family":"Jaffe","sequence":"additional","affiliation":[{"name":"2Laboratory of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlend B.","family":"Smeland","sequence":"additional","affiliation":[{"name":"10Department of Immunology, Rikshospitalet-Radiumhospitalet Medical Center, 0805 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I.","family":"Fisher","sequence":"additional","affiliation":[{"name":"11Southwest Oncology Group, San Antonio, TX 78245"},{"name":"12James P. 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