{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:15:48Z","timestamp":1791900948545,"version":"4.3.4"},"reference-count":26,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,9,3]]},"abstract":"<jats:p>Trafficking of immune cells is controlled by directed migration of relevant cells toward chemotactic signals. Actin cytoskeleton undergoes continuous remodeling and serves as machinery for cell migration. The mDia family of formins and the Wiskott-Aldrich syndrome protein (WASP)\u2013Arp2\/3 system are two major actin nucleating\u2013polymerizing systems in mammalian cells, with the former producing long straight actin filaments and the latter producing branched actin meshwork. Although much is known about the latter, the physiological functions of mDia proteins are unclear. We generated mice deficient in one mDia isoform, mDia1. Although mDia1\u2212\/\u2212 mice were born and developed without apparent abnormality, mDia1\u2212\/\u2212 T lymphocytes exhibited impaired trafficking to secondary lymphoid organs in vivo and showed reduced chemotaxis, little actin filament formation, and impaired polarity in response to chemotactic stimuli in vitro. Similarly, mDia1\u2212\/\u2212 thymocytes showed reduced chemotaxis and impaired egression from the thymus. These results suggest that mDia1 plays a distinct role in chemotaxis in T lymphocyte trafficking.<\/jats:p>","DOI":"10.1084\/jem.20062647","type":"journal-article","created":{"date-parts":[[2007,8,6]],"date-time":"2007-08-06T20:54:38Z","timestamp":1186433678000},"page":"2031-2038","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":119,"title":["Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1"],"prefix":"10.1084","volume":"204","author":[{"given":"Daiji","family":"Sakata","sequence":"first","affiliation":[{"name":"1Department of Pharmacology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology"},{"name":"2Horizontal Medical Research Organization,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Yasuda","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology"},{"name":"2Horizontal Medical Research Organization,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Adachi-Morishima","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Hamazaki","sequence":"additional","affiliation":[{"name":"3Department of Immunology and Cell Biology, Kyoto University Faculty of Medicine, Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Nakayama","sequence":"additional","affiliation":[{"name":"4Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology, RIKEN Kobe Institute, Kobe 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Miki","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagahiro","family":"Minato","sequence":"additional","affiliation":[{"name":"3Department of Immunology and Cell Biology, Kyoto University Faculty of Medicine, Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuh","family":"Narumiya","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,8,6]]},"reference":[{"key":"2023072516020720000_BIB1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.immunol.23.021704.115628","volume":"23","year":"2005","journal-title":"Annu. 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