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CCL3 induces a rapid TNF-\u03b1 secretion by innate inflammatory mononuclear phagocytic cells (MPCs), which further promotes the production of radical oxygen intermediates (ROIs) by both MPCs and neutrophils. ROI generation is the final bactericidal mechanism involved in L. monocytogenes clearance. These results therefore uncover two levels of regulation of the antibacterial secondary protective response: (a) an antigen-dependent phase in which memory CD8+ T cells are reactivated and control the activation of the innate immune system, and (b) an antigen-independent phase in which the MPCs coordinate innate immunity and promote the bactericidal effector activities. In this context, CCL3-secreting memory CD8+ T cells are able to mediate \u201cbystander\u201d killing of an unrelated pathogen upon antigen-specific reactivation, a mechanism that may be important for the design of therapeutic vaccines.<\/jats:p>","DOI":"10.1084\/jem.20070204","type":"journal-article","created":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T20:40:14Z","timestamp":1187037614000},"page":"2075-2087","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":96,"title":["Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF\/ROI+ phagocytes"],"prefix":"10.1084","volume":"204","author":[{"given":"Emilie","family":"Narni-Mancinelli","sequence":"first","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale E-344, Groupe Avenir, Institut de Pharmacologie Mole\u0301culaire et Cellulaire, 06560 Valbonne, France"},{"name":"2Universite\u0301 de Nice-Sophia Antipolis, UFR Sciences, 06108 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Campisi","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale E-344, Groupe Avenir, Institut de Pharmacologie Mole\u0301culaire et Cellulaire, 06560 Valbonne, France"},{"name":"2Universite\u0301 de Nice-Sophia Antipolis, UFR Sciences, 06108 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Bassand","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale E-344, Groupe Avenir, Institut de Pharmacologie Mole\u0301culaire et Cellulaire, 06560 Valbonne, France"},{"name":"2Universite\u0301 de Nice-Sophia Antipolis, UFR Sciences, 06108 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Cazareth","sequence":"additional","affiliation":[{"name":"2Universite\u0301 de Nice-Sophia Antipolis, UFR Sciences, 06108 Nice, France"},{"name":"3Centre National de la Recherche Scientifique, UMR6097, 06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Gounon","sequence":"additional","affiliation":[{"name":"2Universite\u0301 de Nice-Sophia Antipolis, UFR Sciences, 06108 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Glaichenhaus","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale E-344, Groupe Avenir, Institut de Pharmacologie Mole\u0301culaire et Cellulaire, 06560 Valbonne, France"},{"name":"2Universite\u0301 de Nice-Sophia Antipolis, UFR Sciences, 06108 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gre\u0301goire","family":"Lauvau","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale E-344, Groupe Avenir, Institut de Pharmacologie Mole\u0301culaire et Cellulaire, 06560 Valbonne, France"},{"name":"2Universite\u0301 de Nice-Sophia Antipolis, UFR Sciences, 06108 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,8,13]]},"reference":[{"key":"2023072516130166600_BIB1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.immunol.18.1.275","volume":"18","year":"2000","journal-title":"Annu. 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