{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:57:46Z","timestamp":1792807066735,"version":"4.5.0"},"reference-count":41,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,8,6]]},"abstract":"<jats:p>Listeria monocytogenes is a food-borne bacterial pathogen that causes systemic infection by traversing the intestinal mucosa. Although MyD88-mediated signals are essential for defense against systemic L. monocytogenes infection, the role of Toll-like receptor and MyD88 signaling in intestinal immunity against this pathogen has not been defined. We show that clearance of L. monocytogenes from the lumen of the distal small intestine is impaired in MyD88\u2212\/\u2212 mice. The distal ileum of wild-type (wt) mice expresses high levels of RegIII\u03b3, which is a bactericidal lectin that is secreted into the bowel lumen, whereas RegIII\u03b3 expression in MyD88\u2212\/\u2212 mice is nearly undetectable. In vivo depletion of RegIII\u03b3 from the small intestine of wt mice diminishes killing of luminal L. monocytogenes, whereas reconstitution of MyD88-deficient mice with recombinant RegIII\u03b3 enhances intestinal bacterial clearance. Experiments with bone marrow chimeric mice reveal that MyD88-mediated signals in nonhematopoietic cells induce RegIII\u03b3 expression in the small intestine, thereby enhancing bacterial killing. Our findings support a model of MyD88-mediated epithelial conditioning that protects the intestinal mucosa against bacterial invasion by inducing RegIII\u03b3.<\/jats:p>","DOI":"10.1084\/jem.20070563","type":"journal-article","created":{"date-parts":[[2007,7,16]],"date-time":"2007-07-16T20:40:59Z","timestamp":1184618459000},"page":"1891-1900","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":377,"title":["MyD88-mediated signals induce the bactericidal lectin RegIII\u03b3 and protect mice against intestinal\n                    <i>Listeria monocytogenes<\/i>\n                    infection"],"prefix":"10.1084","volume":"204","author":[{"given":"Katharina","family":"Brandl","sequence":"first","affiliation":[{"name":"1Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan-Kettering Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Plitas","sequence":"additional","affiliation":[{"name":"2Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Schnabl","sequence":"additional","affiliation":[{"name":"3Department of Medicine, Columbia University, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P.","family":"DeMatteo","sequence":"additional","affiliation":[{"name":"2Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric G.","family":"Pamer","sequence":"additional","affiliation":[{"name":"1Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan-Kettering Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,7,16]]},"reference":[{"key":"2023072516245245200_BIB1","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1001\/jama.1989.03420090077035","volume":"261","year":"1989","journal-title":"JAMA."},{"key":"2023072516245245200_BIB2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1056\/NEJM199603213341206","volume":"334","year":"1996","journal-title":"N. 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