{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:46:15Z","timestamp":1791071175989,"version":"4.1.0"},"reference-count":58,"publisher":"Rockefeller University Press","issue":"7","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,7,9]]},"abstract":"<jats:p>We examined the role of the antiapoptotic molecule Bcl-2 in combating the proapoptotic molecule Bim in control of naive and memory T cell homeostasis using Bcl-2\u2212\/\u2212 mice that were additionally deficient in one or both alleles of Bim. Naive T cells were significantly decreased in Bim+\/\u2212Bcl-2\u2212\/\u2212 mice, but were largely restored in Bim\u2212\/\u2212Bcl-2\u2212\/\u2212 mice. Similarly, a synthetic Bcl-2 inhibitor killed wild-type, but not Bim\u2212\/\u2212, T cells. Further, T cells from Bim+\/\u2212Bcl-2\u2212\/\u2212 mice died rapidly ex vivo and were refractory to cytokine-driven survival in vitro. In vivo, naive CD8+ T cells required Bcl-2 to combat Bim to maintain peripheral survival, whereas naive CD4+ T cells did not. In contrast, Bim+\/\u2212Bcl-2\u2212\/\u2212 mice generated relatively normal numbers of memory T cells after lymphocytic choriomeningitis virus infection. Accumulation of memory T cells in Bim+\/\u2212Bcl-2\u2212\/\u2212 mice was likely caused by their increased proliferative renewal because of the lymphopenic environment of the mice. Collectively, these data demonstrate a critical role for a balance between Bim and Bcl-2 in controlling homeostasis of naive and memory T cells.<\/jats:p>","DOI":"10.1084\/jem.20070618","type":"journal-article","created":{"date-parts":[[2007,6,25]],"date-time":"2007-06-25T20:53:46Z","timestamp":1182804826000},"page":"1665-1675","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":194,"title":["Bim\/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis"],"prefix":"10.1084","volume":"204","author":[{"given":"Sara","family":"Wojciechowski","sequence":"first","affiliation":[{"name":"1Division of Immunobiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pulak","family":"Tripathi","sequence":"additional","affiliation":[{"name":"1Division of Immunobiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Bourdeau","sequence":"additional","affiliation":[{"name":"1Division of Immunobiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Acero","sequence":"additional","affiliation":[{"name":"2Division of Endocrinology, Cincinnati Children's Hospital, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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