{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:24:29Z","timestamp":1780385069527,"version":"3.54.1"},"reference-count":52,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,1,21]]},"abstract":"<jats:p>Lyme arthritis results from colonization of joints by Borrelia burgdorferi and the ensuing host response. Using gene array\u2013based differential analysis of B. burgdorferi gene expression and quantitative reverse trancription-polymerase chain reaction, we identified two paralogous spirochete genes, bmpA and bmpB, that are preferentially up-regulated in mouse joints compared with other organs. Transfer of affinity-purified antibodies against either BmpA or BmpB into B. burgdorferi\u2013infected mice selectively reduced spirochete numbers and inflammation in the joints. B. burgdorferi lacking bmpA\/B were therefore generated to further explore the role of these proteins in the pathogenesis of Lyme disease. B. burgdorferi lacking bmpA\/B were infectious in mice, but unable to persist in the joints, and they failed to induce severe arthritis. Complementation of the mutant spirochetes with a wild-type copy of the bmpA and bmpB genes partially restored the original phenotype. These data delineate a role for differentially produced B. burgdorferi antigens in spirochete colonization of mouse joints, and suggest new strategies for the treatment of Lyme arthritis.<\/jats:p>","DOI":"10.1084\/jem.20070962","type":"journal-article","created":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T01:13:27Z","timestamp":1199150007000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["<i>Borrelia burgdorferi<\/i> basic membrane proteins A and B participate in the genesis of Lyme arthritis"],"prefix":"10.1084","volume":"205","author":[{"given":"Utpal","family":"Pal","sequence":"first","affiliation":[{"name":"1Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghua","family":"Wang","sequence":"additional","affiliation":[{"name":"1Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukai","family":"Bao","sequence":"additional","affiliation":[{"name":"1Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Yang","sequence":"additional","affiliation":[{"name":"2Department of Veterinary Medicine, University of Maryland, College Park, MD 20742"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapna","family":"Samanta","sequence":"additional","affiliation":[{"name":"1Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schoen","sequence":"additional","affiliation":[{"name":"1Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Wormser","sequence":"additional","affiliation":[{"name":"3Division of Infectious Diseases, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Schwartz","sequence":"additional","affiliation":[{"name":"4Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[{"name":"1Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,12,31]]},"reference":[{"key":"2023072915355975600_BIB1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nri1267","volume":"4","year":"2004","journal-title":"Nat. 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