{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:38:20Z","timestamp":1791293900120,"version":"4.1.0"},"reference-count":29,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,11,26]]},"abstract":"<jats:p>We previously reported that joint swelling, synovial thickening, and cartilage matrix depletion induced by the injection of anti-collagen monoclonal antibodies and lipopolysaccharide (LPS) in BALB\/c mice are increased in the absence of inhibitory leukocyte immunoglobulin (Ig)-like receptor B4 (LILRB4; formerly gp49B1) in a neutrophil-dependent manner. Because both mast cells and neutrophils express LILRB4, we sought a mast cell requirement with mast cell\u2013deficient mouse strains, but unexpectedly obtained full arthritis in KitW-sh mice and full resistance in KitW\/KitW-v mice. KitW-sh mice were indeed mast cell deficient as assessed by histology and the absence of IgE\/mast cell\u2013dependent passive cutaneous anaphylaxis in the ear and joint as well as passive systemic anaphylaxis. Deletion of LILRB4 in KitW-sh mice exacerbated anti-collagen\/LPS-induced joint swelling that was abolished by neutrophil depletion, establishing a counterregulatory role for LILRB4 in the absence of mast cells. Whereas blood neutrophil levels and LPS-elicited tissue neutrophilia were equal in KitW-sh and Kit+ mice, both were impaired in KitW\/KitW-v mice. Although both strains are mast cell deficient and protected from IgE-mediated anaphylactic reactions, their dramatically different responses to autoantibody-mediated, neutrophil-dependent immune complex arthritis suggest that other host differences determine the extent of mast cell involvement. Thus, a conclusion for an absolute mast cell role in a pathobiologic process requires evidence from both strains.<\/jats:p>","DOI":"10.1084\/jem.20071391","type":"journal-article","created":{"date-parts":[[2007,11,13]],"date-time":"2007-11-13T02:06:31Z","timestamp":1194919591000},"page":"2797-2802","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":146,"title":["Mast cell deficiency in <i>KitW-sh<\/i> mice does not impair antibody-mediated arthritis"],"prefix":"10.1084","volume":"204","author":[{"given":"Joseph S.","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Friend","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Frank","family":"Austen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard R.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,11,12]]},"reference":[{"key":"2023072515320935700_BIB1","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1002\/eji.200425895","volume":"35","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"2023072515320935700_BIB2","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1084\/jem.20030906","volume":"198","year":"2003","journal-title":"J. Exp. 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