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Nested long-range PCR analysis indicated a low frequency of homologous recombination leading to MYB tandem duplication in the peripheral blood mononuclear cells of \u223c50% of healthy individuals, none of whom had a MYB duplication in the germline. We conclude that Alu-mediated MYB tandem duplication occurs at low frequency during normal thymocyte development and is clonally selected during the molecular pathogenesis of human T-ALL.<\/jats:p>","DOI":"10.1084\/jem.20071637","type":"journal-article","created":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T01:35:19Z","timestamp":1197336919000},"page":"3059-3066","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":93,"title":["Alu elements mediate <i>MYB<\/i> gene tandem duplication in human T-ALL"],"prefix":"10.1084","volume":"204","author":[{"given":"Jennifer","family":"O'Neil","sequence":"first","affiliation":[{"name":"1Department of Pediatric Oncology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Tchinda","sequence":"additional","affiliation":[{"name":"5Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"1Department of Pediatric Oncology,"},{"name":"6Division of Hematology, Children's Hospital Boston, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Moreau","sequence":"additional","affiliation":[{"name":"1Department of Pediatric Oncology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Maser","sequence":"additional","affiliation":[{"name":"2Department of Medical Oncology,"},{"name":"7Department of Genetics and Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Kin","family":"Wong","sequence":"additional","affiliation":[{"name":"2Department of Medical Oncology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"3Department of Biostatistics and Computational Biology, and"},{"name":"9Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"McKenna","sequence":"additional","affiliation":[{"name":"1Department of Pediatric Oncology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. 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