{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:13:51Z","timestamp":1791180831195,"version":"4.1.0"},"reference-count":47,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,3,17]]},"abstract":"<jats:p>Members of the Bcl-2 protein family play crucial roles in the maintenance of tissue homeostasis by regulating apoptosis in response to developmental cues or exogenous stress. Proapoptotic BH3-only members of the Bcl-2 family are essential for initiation of cell death, and they function by activating the proapoptotic Bcl-2 family members Bax and\/or Bak, either directly or indirectly through binding to prosurvival Bcl-2 family members. Bax and Bak then elicit the downstream events in apoptosis signaling. Mammals have at least eight BH3-only proteins and they are activated in a stimulus-specific, as well as a cell type\u2013specific, manner. We have generated mice lacking the BH3-only protein Bcl-2\u2013modifying factor (Bmf) to investigate its role in cell death signaling. Our studies reveal that Bmf is dispensable for embryonic development and certain forms of stress-induced apoptosis, including loss of cell attachment (anoikis) or UV irradiation. Remarkably, loss of Bmf protected lymphocytes against apoptosis induced by glucocorticoids or histone deacetylase inhibition. Moreover, bmf\u2212\/\u2212 mice develop a B cell\u2013restricted lymphadenopathy caused by the abnormal resistance of these cells to a range of apoptotic stimuli. Finally, Bmf-deficiency accelerated the development of \u03b3 irradiation\u2013induced thymic lymphomas. Our results demonstrate that Bmf plays a critical role in apoptosis signaling and can function as a tumor suppressor.<\/jats:p>","DOI":"10.1084\/jem.20071658","type":"journal-article","created":{"date-parts":[[2008,2,25]],"date-time":"2008-02-25T20:59:47Z","timestamp":1203973187000},"page":"641-655","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":120,"title":["Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates \u03b3 irradiation\u2013induced thymic lymphoma development"],"prefix":"10.1084","volume":"205","author":[{"given":"Verena","family":"Labi","sequence":"first","affiliation":[{"name":"1Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Erlacher","sequence":"additional","affiliation":[{"name":"1Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kiessling","sequence":"additional","affiliation":[{"name":"1Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Manzl","sequence":"additional","affiliation":[{"name":"1Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Frenzel","sequence":"additional","affiliation":[{"name":"1Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Strasser","sequence":"additional","affiliation":[{"name":"2The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Villunger","sequence":"additional","affiliation":[{"name":"1Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2008,2,25]]},"reference":[{"key":"2023072915512848300_BIB1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nri1568","volume":"5","year":"2005","journal-title":"Nat. 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