{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:49:59Z","timestamp":1790905799826,"version":"4.1.0"},"reference-count":31,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,3,17]]},"abstract":"<jats:p>Therapeutic vaccination is a potentially powerful strategy to establish immune control and eradicate persistent viral infections. Large and multifunctional antiviral T cell responses are associated with control of viral persistence; however, for reasons that were mostly unclear, current therapeutic vaccination approaches to restore T cell immunity and control viral infection have been ineffective. Herein, we confirmed that neutralization of the immunosuppressive factor interleukin (IL)-10 stimulated T cell responses and improved control of established persistent lymphocytic choriomeningitis virus (LCMV) infection. Importantly, blockade of IL-10 also allowed an otherwise ineffective therapeutic DNA vaccine to further stimulate antiviral immunity, thereby increasing T cell responses and enhancing clearance of persistent LCMV replication. We therefore propose that a reason that current therapeutic vaccination strategies fail to resurrect\/sustain T cell responses is because they do not alleviate the immunosuppressive environment. Consequently, blocking key suppressive factors could render ineffective vaccines more efficient at improving T cell immunity, and thereby allow immune-mediated control of persistent viral infection.<\/jats:p>","DOI":"10.1084\/jem.20071948","type":"journal-article","created":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T16:58:35Z","timestamp":1205254715000},"page":"533-541","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":131,"title":["IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection"],"prefix":"10.1084","volume":"205","author":[{"given":"David G.","family":"Brooks","sequence":"first","affiliation":[{"name":"1Viral-Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Lee","sequence":"additional","affiliation":[{"name":"1Viral-Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Elsaesser","sequence":"additional","affiliation":[{"name":"1Viral-Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorian B.","family":"McGavern","sequence":"additional","affiliation":[{"name":"1Viral-Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.A.","family":"Oldstone","sequence":"additional","affiliation":[{"name":"1Viral-Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience,"},{"name":"2Department of Infectology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2008,3,10]]},"reference":[{"key":"2023072915343484700_BIB1","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1084\/jem.188.12.2205","volume":"188","year":"1998","journal-title":"J. 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