{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:29:19Z","timestamp":1791412159477,"version":"4.3.3"},"reference-count":50,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,3,16]]},"abstract":"<jats:p>CX3CR1 expression is associated with the commitment of CSF-1R+ myeloid precursors to the macrophage\/dendritic cell (DC) lineage. However, the relationship of the CSF-1R+ CX3CR1+ macrophage\/DC precursor (MDP) with other DC precursors and the role of CX3CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1+ inflammatory monocytes that differentiate into TipDCs during infection. CX3CR1 deficiency selectively impairs the recruitment of blood Gr1+ monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.<\/jats:p>","DOI":"10.1084\/jem.20081385","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T01:23:50Z","timestamp":1236648230000},"page":"595-606","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":391,"title":["CX3CR1+ CD115+ CD135+ common macrophage\/DC precursors and the role of CX3CR1 in their response to inflammation"],"prefix":"10.1084","volume":"206","author":[{"given":"Cedric","family":"Auffray","sequence":"first","affiliation":[{"name":"Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U838, Universit\u00e9 Paris-Descartes, 75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin K.","family":"Fogg","sequence":"additional","affiliation":[{"name":"Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U838, Universit\u00e9 Paris-Descartes, 75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Narni-Mancinelli","sequence":"additional","affiliation":[{"name":"INSERM U924, Universit\u00e9 de Nice-Sophia Antipolis, 06560 Valbonne, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Senechal","sequence":"additional","affiliation":[{"name":"Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U838, Universit\u00e9 Paris-Descartes, 75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Trouillet","sequence":"additional","affiliation":[{"name":"Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U838, Universit\u00e9 Paris-Descartes, 75015 Paris, France 1"},{"name":"Centre for inflammation Biology, Division of Immunity, Infection, and Inflammatory Diseases, King's College London, SE1 9RT London, England, UK 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Saederup","sequence":"additional","affiliation":[{"name":"Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA 94158 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Leemput","sequence":"additional","affiliation":[{"name":"Centre d'etude et de recherche therapeutique en ophtalmologie, Universit\u00e9 Paris-Descartes, 75015 Paris, France 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Bigot","sequence":"additional","affiliation":[{"name":"Centre d'etude et de recherche therapeutique en ophtalmologie, Universit\u00e9 Paris-Descartes, 75015 Paris, France 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Campisi","sequence":"additional","affiliation":[{"name":"INSERM U924, Universit\u00e9 de Nice-Sophia Antipolis, 06560 Valbonne, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Abitbol","sequence":"additional","affiliation":[{"name":"Centre d'etude et de recherche therapeutique en ophtalmologie, Universit\u00e9 Paris-Descartes, 75015 Paris, France 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Molina","sequence":"additional","affiliation":[{"name":"Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U838, Universit\u00e9 Paris-Descartes, 75015 Paris, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Charo","sequence":"additional","affiliation":[{"name":"Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA 94158 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hume","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, EH25 9PS Roslin, Scotland, UK 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cumano","sequence":"additional","affiliation":[{"name":"INSERM U668, Unit\u00e9 de D\u00e9veloppement des Lymphocytes, Institut Pasteur, 75015 Paris, France 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregoire","family":"Lauvau","sequence":"additional","affiliation":[{"name":"INSERM U924, Universit\u00e9 de Nice-Sophia Antipolis, 06560 Valbonne, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Geissmann","sequence":"additional","affiliation":[{"name":"Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U838, Universit\u00e9 Paris-Descartes, 75015 Paris, France 1"},{"name":"Centre for inflammation Biology, Division of Immunity, Infection, and Inflammatory Diseases, King's College London, SE1 9RT London, England, UK 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2009,3,9]]},"reference":[{"key":"2023072916411777300_bib1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1182\/blood-2002-02-0569","article-title":"A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse","volume":"101","author":"Sasmono","year":"2003","journal-title":"Blood."},{"key":"2023072916411777300_bib2","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.4049\/jimmunol.175.3.1399","article-title":"The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion","volume":"175","author":"MacDonald","year":"2005","journal-title":"J. Immunol."},{"key":"2023072916411777300_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature."},{"key":"2023072916411777300_bib4","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0092-8674(02)01201-1","article-title":"Pattern recognition receptors: doubling up for the innate immune response","volume":"111","author":"Gordon","year":"2002","journal-title":"Cell."},{"key":"2023072916411777300_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1074-7613(03)00178-X","article-title":"Monocyte heterogeneity and innate immunity","volume":"19","author":"Taylor","year":"2003","journal-title":"Immunity."},{"key":"2023072916411777300_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nri746","article-title":"Mouse and human dendritic cell subtypes","volume":"2","author":"Shortman","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2023072916411777300_bib7","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.1154370","article-title":"Discovery of a cytokine and its receptor by functional screening of the extracellular proteome","volume":"320","author":"Lin","year":"2008","journal-title":"Science."},{"key":"2023072916411777300_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood.V99.1.111","article-title":"Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects","volume":"99","author":"Dai","year":"2002","journal-title":"Blood."},{"key":"2023072916411777300_bib9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ni.1615","article-title":"The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues","volume":"9","author":"Waskow","year":"2008","journal-title":"Nat. Immunol."},{"key":"2023072916411777300_bib10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.immuni.2005.02.007","article-title":"Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells","volume":"22","author":"Kabashima","year":"2005","journal-title":"Immunity."},{"key":"2023072916411777300_bib11","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1084\/jem.184.5.1953","article-title":"Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified","volume":"184","author":"Maraskovsky","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023072916411777300_bib12","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1182\/blood.V95.11.3489","article-title":"Mice lacking Flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells","volume":"95","author":"McKenna","year":"2000","journal-title":"Blood."},{"key":"2023072916411777300_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1084\/jem.20030107","article-title":"The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3","volume":"198","author":"D'Amico","year":"2003","journal-title":"J. Exp. Med."},{"key":"2023072916411777300_bib14","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1182\/blood.V88.6.2004.bloodjournal8862004","article-title":"Hematologic effects of flt3 ligand in vivo in mice","volume":"88","author":"Brasel","year":"1996","journal-title":"Blood."},{"key":"2023072916411777300_bib15","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1210\/endo.134.4.8137761","article-title":"Granulocyte-macrophage colony-stimulating factor corrects macrophage deficiencies, but not osteopetrosis, in the colony-stimulating factor-1-deficient op\/op mouse","volume":"134","author":"Wiktor-Jedrzejczak","year":"1994","journal-title":"Endocrinology."},{"key":"2023072916411777300_bib16","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jlb.66.2.252","article-title":"Regulation of dendritic cell trafficking: a process that involves the participation of selective chemokines","volume":"66","author":"Dieu-Nosjean","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"2023072916411777300_bib17","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.186.10.1757","article-title":"Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor","volume":"186","author":"Kurihara","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023072916411777300_bib18","doi-asserted-by":"crossref","first-page":"14944","DOI":"10.1073\/pnas.95.25.14944","article-title":"Mature monocytic cells enter tissues and engraft","volume":"95","author":"Kennedy","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072916411777300_bib19","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1073\/pnas.90.7.3038","article-title":"Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow","volume":"90","author":"Inaba","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072916411777300_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1749-6632.2001.tb03586.x","article-title":"Dendritic cell development from common myeloid progenitors","volume":"938","author":"Manz","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2023072916411777300_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature."},{"key":"2023072916411777300_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1117729","article-title":"A clonogenic bone marrow progenitor specific for macrophages and dendritic cells","volume":"311","author":"Fogg","year":"2006","journal-title":"Science."},{"key":"2023072916411777300_bib23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1084\/jem.20061011","article-title":"Monocytes give rise to mucosal, but not splenic, conventional dendritic cells","volume":"204","author":"Varol","year":"2007","journal-title":"J. Exp. Med."},{"key":"2023072916411777300_bib24","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ni1522","article-title":"Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo","volume":"8","author":"Naik","year":"2007","journal-title":"Nat. Immunol."},{"key":"2023072916411777300_bib25","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/ni1518","article-title":"Identification of clonogenic common Flt3(+)M-CSFR(+) plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow","volume":"8","author":"Onai","year":"2007","journal-title":"Nat. Immunol."},{"key":"2023072916411777300_bib26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1034\/j.1600-6143.2003.00068.x","article-title":"Blockade of macrophage colony-stimulating factor reduces macrophage proliferation and accumulation in renal allograft rejection","volume":"3","author":"Jose","year":"2003","journal-title":"Am. J. Transplant."},{"key":"2023072916411777300_bib27","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1161\/01.CIR.99.13.1740","article-title":"Intraperitoneal administration of anti-c-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein E-deficient mice","volume":"99","author":"Murayama","year":"1999","journal-title":"Circulation."},{"key":"2023072916411777300_bib28","first-page":"2469","article-title":"Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M","volume":"11","author":"Sudo","year":"1995","journal-title":"Oncogene."},{"key":"2023072916411777300_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity."},{"key":"2023072916411777300_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0165-2478(98)00058-3","article-title":"Establishment and characterization of pro-B cell lines from motheaten mutant mouse defective in SHP-1 protein tyrosine phosphatase","volume":"63","author":"Miyamoto","year":"1998","journal-title":"Immunol. Lett."},{"key":"2023072916411777300_bib31","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1172\/JCI26132","article-title":"M-CSF mediates TNF-induced inflammatory osteolysis","volume":"115","author":"Kitaura","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2023072916411777300_bib32","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J. Exp. Med."},{"key":"2023072916411777300_bib33","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)80438-9","article-title":"Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion","volume":"91","author":"Imai","year":"1997","journal-title":"Cell."},{"key":"2023072916411777300_bib34","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2023072916411777300_bib35","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1128\/MCB.21.9.3159-3165.2001","article-title":"Generation and analysis of mice lacking the chemokine fractalkine","volume":"21","author":"Cook","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2023072916411777300_bib36","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1172\/JCI15555","article-title":"Decreased atherosclerosis in CX3CR1\u2212\/\u2212 mice reveals a role for fractalkine in atherogenesis","volume":"111","author":"Lesnik","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2023072916411777300_bib37","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1002\/(SICI)1521-4141(199906)29:06<1925::AID-IMMU1925>3.0.CO;2-U","article-title":"Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells","volume":"29","author":"Kanazawa","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"2023072916411777300_bib38","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20022156","article-title":"Fractalkine preferentially mediates arrest and migration of CD16+ monocytes","volume":"197","author":"Ancuta","year":"2003","journal-title":"J. Exp. Med."},{"key":"2023072916411777300_bib39","doi-asserted-by":"crossref","first-page":"34183","DOI":"10.1074\/jbc.M005731200","article-title":"Unique role of the chemokine domain of fractalkine in cell capture. Kinetics of receptor dissociation correlate with cell adhesion","volume":"275","author":"Haskell","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2023072916411777300_bib40","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1084\/jem.188.8.1413","article-title":"Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow","volume":"188","author":"Fong","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072916411777300_bib41","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.4049\/jimmunol.164.8.4313","article-title":"CX3C-chemokine, fractalkine-enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and -independent mechanisms","volume":"164","author":"Goda","year":"2000","journal-title":"J. Immunol."},{"key":"2023072916411777300_bib42","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science."},{"key":"2023072916411777300_bib43","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nn1715","article-title":"Control of microglial neurotoxicity by the fractalkine receptor","volume":"9","author":"Cardona","year":"2006","journal-title":"Nat. Neurosci."},{"key":"2023072916411777300_bib44","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S1074-7613(03)00330-3","article-title":"Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity."},{"key":"2023072916411777300_bib45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"2023072916411777300_bib46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","article-title":"TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity."},{"key":"2023072916411777300_bib47","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.4049\/jimmunol.180.5.3019","article-title":"Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations","volume":"180","author":"Jakubzick","year":"2008","journal-title":"J. Immunol."},{"key":"2023072916411777300_bib48","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/gast.2002.30329","article-title":"Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells","volume":"122","author":"Brand","year":"2002","journal-title":"Gastroenterology."},{"key":"2023072916411777300_bib49","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1158\/0008-5472.CAN-03-3437","article-title":"CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells","volume":"64","author":"Shulby","year":"2004","journal-title":"Cancer Res."},{"key":"2023072916411777300_bib50","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites","volume":"117","author":"Tsou","year":"2007","journal-title":"J. Clin. Invest."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/206\/3\/595\/1901533\/jem_20081385.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/206\/3\/595\/1901533\/jem_20081385.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T16:42:11Z","timestamp":1690648931000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/206\/3\/595\/40416\/CX3CR1-CD115-CD135-common-macrophage-DC-precursors"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,9]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3,16]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20081385","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3,9]]}}}