{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:08:37Z","timestamp":1791079717603,"version":"4.1.0"},"reference-count":66,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,3,16]]},"abstract":"<jats:p>Intestinal epithelial cells (IECs) produce thymic stromal lymphopoietin (TSLP); however, the in vivo influence of TSLP\u2013TSLP receptor (TSLPR) interactions on immunity and inflammation in the intestine remains unclear. We show that TSLP\u2013TSLPR interactions are critical for immunity to the intestinal pathogen Trichuris. Monoclonal antibody\u2013mediated neutralization of TSLP or deletion of the TSLPR in normally resistant mice resulted in defective expression of Th2 cytokines and persistent infection. Susceptibility was accompanied by elevated expression of interleukin (IL) 12\/23p40, interferon (IFN) \u03b3, and IL-17A, and development of severe intestinal inflammation. Critically, neutralization of IFN-\u03b3 in Trichuris-infected TSLPR\u2212\/\u2212 mice restored Th2 cytokine responses and resulted in worm expulsion, providing the first demonstration of TSLPR-independent pathways for Th2 cytokine production. Additionally, TSLPR\u2212\/\u2212 mice displayed elevated production of IL-12\/23p40 and IFN-\u03b3, and developed heightened intestinal inflammation upon exposure to dextran sodium sulfate, demonstrating a previously unrecognized immunoregulatory role for TSLP in a mouse model of inflammatory bowel disease.<\/jats:p>","DOI":"10.1084\/jem.20081499","type":"journal-article","created":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T21:23:50Z","timestamp":1236633830000},"page":"655-667","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":304,"title":["TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis"],"prefix":"10.1084","volume":"206","author":[{"given":"Betsy C.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colby","family":"Zaph","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Troy","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Guild","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Comeau","sequence":"additional","affiliation":[{"name":"Inflammation Research, Amgen Inc., Seattle, WA 98119 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Artis","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2009,3,9]]},"reference":[{"key":"2023072916443350200_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature05698","article-title":"Epithelial NEMO links innate immunity to chronic intestinal inflammation","volume":"446","author":"Nenci","year":"2007","journal-title":"Nature."},{"key":"2023072916443350200_bib2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nature05590","article-title":"Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis","volume":"446","author":"Zaph","year":"2007","journal-title":"Nature."},{"key":"2023072916443350200_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2567.2007.02687.x","article-title":"Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-beta","volume":"123","author":"Zeuthen","year":"2008","journal-title":"Immunology."},{"key":"2023072916443350200_bib4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.immunol.25.022106.141718","article-title":"TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation","volume":"25","author":"Liu","year":"2007","journal-title":"Annu. 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