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Staphylococcal synthesis of adenosine in blood, escape from phagocytic clearance, and subsequent formation of organ abscesses were all dependent on adsA and could be rescued by an exogenous supply of adenosine. An AdsA homologue was identified in the anthrax pathogen, and adenosine synthesis also enabled escape of Bacillus anthracis from phagocytic clearance. Collectively, these results suggest that staphylococci and other bacterial pathogens exploit the immunomodulatory attributes of adenosine to escape host immune responses.<\/jats:p>","DOI":"10.1084\/jem.20090097","type":"journal-article","created":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T21:16:27Z","timestamp":1254172587000},"page":"2417-2427","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":240,"title":["<i>Staphylococcus aureus<\/i>\n                    synthesizes adenosine to escape host immune responses"],"prefix":"10.1084","volume":"206","author":[{"given":"Vilasack","family":"Thammavongsa","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin W.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique M.","family":"Missiakas","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Schneewind","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2009,9,28]]},"reference":[{"key":"2023072917390908300_bib1","doi-asserted-by":"publisher","first-page":"12312","DOI":"10.1073\/pnas.0404728101","article-title":"Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing","volume":"101","author":"Bae","year":"2004","journal-title":"Proc. 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