{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:27:51Z","timestamp":1791293271150,"version":"4.1.0"},"reference-count":33,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,10,26]]},"abstract":"<jats:p>Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of death in hepatitis C virus and schistosome infections. Hepatic fibrosis (HF) may develop either slowly or rapidly in schistosome-infected subjects. This depends, in part, on a major genetic control exerted by genes of chromosome 6q23. A gene (connective tissue growth factor [CTGF]) is located in that region that encodes a strongly fibrogenic molecule. We show that the single nucleotide polymorphism (SNP) rs9402373 that lies close to CTGF is associated with severe HF (P = 2 \u00d7 10\u22126; odds ratio [OR] = 2.01; confidence interval of OR [CI] = 1.51\u20132.7) in two Chinese samples, in Sudanese, and in Brazilians infected with either Schistosoma japonicum or S. mansoni. Furthermore, SNP rs12526196, also located close to CTGF, is independently associated with severe fibrosis (P = 6 \u00d7 10\u22124; OR = 1.94; CI = 1.32\u20132.82) in the Chinese and Sudanese subjects. Both variants affect nuclear factor binding and may alter gene transcription or transcript stability. The identified variants may be valuable markers for the prediction of disease progression, and identify a critical step in the development of HF that could be a target for chemotherapy.<\/jats:p>","DOI":"10.1084\/jem.20090383","type":"journal-article","created":{"date-parts":[[2009,10,12]],"date-time":"2009-10-12T21:12:08Z","timestamp":1255381928000},"page":"2321-2328","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with Schistosomes"],"prefix":"10.1084","volume":"206","author":[{"given":"Alain","family":"Dessein","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U906, 13385 Marseille, France 1"},{"name":"Universit\u00e9 de la M\u00e9diterran\u00e9e, Institut F\u00e9d\u00e9ratif de Recherche 88, Assistance Publique, H\u00f4pitaux de Marseille, 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