{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:01:43Z","timestamp":1792224103005,"version":"4.4.0"},"reference-count":58,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,2,15]]},"abstract":"<jats:p>Chikungunya virus (CHIKV) is the causative agent of an outbreak that began in La R\u00e9union in 2005 and remains a major public health concern in India, Southeast Asia, and southern Europe. CHIKV is transmitted to humans by mosquitoes and the associated disease is characterized by fever, myalgia, arthralgia, and rash. As viral load in infected patients declines before the appearance of neutralizing antibodies, we studied the role of type I interferon (IFN) in CHIKV pathogenesis. Based on human studies and mouse experimentation, we show that CHIKV does not directly stimulate type I IFN production in immune cells. Instead, infected nonhematopoietic cells sense viral RNA in a Cardif-dependent manner and participate in the control of infection through their production of type I IFNs. Although the Cardif signaling pathway contributes to the immune response, we also find evidence for a MyD88-dependent sensor that is critical for preventing viral dissemination. Moreover, we demonstrate that IFN-\u03b1\/\u03b2 receptor (IFNAR) expression is required in the periphery but not on immune cells, as IFNAR\u2212\/\u2212\u2192WT bone marrow chimeras are capable of clearing the infection, whereas WT\u2192IFNAR\u2212\/\u2212 chimeras succumb. This study defines an essential role for type I IFN, produced via cooperation between multiple host sensors and acting directly on nonhematopoietic cells, in the control of CHIKV.<\/jats:p>","DOI":"10.1084\/jem.20090851","type":"journal-article","created":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T22:05:48Z","timestamp":1265061948000},"page":"429-442","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":312,"title":["Type I IFN controls chikungunya virus via its action on nonhematopoietic cells"],"prefix":"10.1084","volume":"207","author":[{"given":"Cl\u00e9mentine","family":"Schilte","sequence":"first","affiliation":[{"name":"Department of Immunology, Unit\u00e9 Immunobiologie des Cellules Dendritiques 1 and 2 , 3 , 4 , 5 , and 6"},{"name":"Laboratory of Lymphoid Tissue Development 1 and 2 , 3 , 4 , 5 , and 6"},{"name":"Department of Infection and Epidemiology, Groupe Microorganismes et Barri\u00e8res de 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