{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:25:55Z","timestamp":1791822355537,"version":"4.3.4"},"reference-count":32,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,6,7]]},"abstract":"<jats:p>The mechanism by which the immune system produces effector and memory T cells is largely unclear. To allow a large-scale assessment of the development of single naive T cells into different subsets, we have developed a technology that introduces unique genetic tags (barcodes) into naive T cells. By comparing the barcodes present in antigen-specific effector and memory T cell populations in systemic and local infection models, at different anatomical sites, and for TCR\u2013pMHC interactions of different avidities, we demonstrate that under all conditions tested, individual naive T cells yield both effector and memory CD8+ T cell progeny. This indicates that effector and memory fate decisions are not determined by the nature of the priming antigen-presenting cell or the time of T cell priming. Instead, for both low and high avidity T cells, individual naive T cells have multiple fates and can differentiate into effector and memory T cell subsets.<\/jats:p>","DOI":"10.1084\/jem.20091175","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T23:25:35Z","timestamp":1274138735000},"page":"1235-1246","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":188,"title":["One naive T cell, multiple fates in CD8+ T cell differentiation"],"prefix":"10.1084","volume":"207","author":[{"given":"Carmen","family":"Gerlach","sequence":"first","affiliation":[{"name":"Division of Immunology 1 , 2 , and 3"},{"name":"Central Microarray Facility 1 , 2 , and 3"},{"name":"Bioinformatics and Statistics Group, Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen W.J.","family":"van Heijst","sequence":"additional","affiliation":[{"name":"Division of Immunology 1 , 2 , and 3"},{"name":"Central Microarray Facility 1 , 2 , and 3"},{"name":"Bioinformatics and Statistics Group, Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Swart","sequence":"additional","affiliation":[{"name":"Division of Immunology 1 , 2 , and 3"},{"name":"Central Microarray Facility 1 , 2 , and 3"},{"name":"Bioinformatics and Statistics Group, Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoud","family":"Sie","sequence":"additional","affiliation":[{"name":"Division of Immunology 1 , 2 , and 3"},{"name":"Central Microarray Facility 1 , 2 , and 3"},{"name":"Bioinformatics and Statistics Group, Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Division of Immunology 1 , 2 , and 3"},{"name":"Central Microarray Facility 1 , 2 , and 3"},{"name":"Bioinformatics and Statistics Group, Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron M.","family":"Kerkhoven","sequence":"additional","affiliation":[{"name":"Division of Immunology 1 , 2 , and 3"},{"name":"Central Microarray Facility 1 , 2 , and 3"},{"name":"Bioinformatics and Statistics Group, Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Zehn","sequence":"additional","affiliation":[{"name":"Swiss Vaccine Research Institute, 1011 Lausanne, Switzerland 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Bevan","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Schepers","sequence":"additional","affiliation":[{"name":"Division of Immunology 1 , 2 , and 3"},{"name":"Central Microarray Facility 1 , 2 , and 3"},{"name":"Bioinformatics and Statistics Group, Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton N.M.","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Division of Immunology 1 , 2 , and 3"},{"name":"Central Microarray Facility 1 , 2 , and 3"},{"name":"Bioinformatics and Statistics Group, Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,5,17]]},"reference":[{"key":"2023072522162580600_bib1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1126\/science.272.5258.54","article-title":"Immunological memory and protective immunity: understanding their relation","volume":"272","author":"Ahmed","year":"1996","journal-title":"Science."},{"key":"2023072522162580600_bib2","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/ni1098","article-title":"CD8+ T cell contraction is controlled by early inflammation","volume":"5","author":"Badovinac","year":"2004","journal-title":"Nat. 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