{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:20:12Z","timestamp":1758820812151},"reference-count":61,"publisher":"Rockefeller University Press","issue":"7","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,7,5]]},"abstract":"<jats:p>Antiinfluenza type 2 (T2) immunity contributes to both immunopathology and immunoprotection, yet the underlying mechanisms modulating T2 immunity remain ill defined. We describe a novel mouse antigen (Ag)-presenting cell (APC), designated late-activator APC (LAPC). After pulmonary influenza A (H1N1) virus infection, LAPCs enter the lungs, capture viral Ag, and subsequently migrate to the draining lymph node (DLN) and spleen, with delayed kinetics relative to dendritic cells (DCs). In the DLN, influenza virus\u2013activated LAPCs present Ag and selectively induce T helper type 2 (Th2) effector cell polarization by cell\u2013cell contact\u2013mediated modulation of GATA-3 expression. In adoptive transfer experiments, influenza virus\u2013activated LAPCs augmented Th2 effector T cell responses in the DLN, increased production of circulating antiinfluenza immunoglobulin, and increased levels of T2 cytokines in bronchoalveolar lavage fluid in recipient influenza virus\u2013infected mice. LAPC-recipient mice exhibited exacerbated pulmonary pathology, with delayed viral clearance and enhanced pulmonary eosinophilia. Collectively, our results identify and highlight the importance of LAPCs as immunomodulators of T2 immunity during influenza A virus infection.<\/jats:p>","DOI":"10.1084\/jem.20091373","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T04:12:34Z","timestamp":1276575154000},"page":"1435-1451","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Identification of a novel antigen-presenting cell population modulating antiinfluenza type 2 immunity"],"prefix":"10.1084","volume":"207","author":[{"given":"Jae-Kwang","family":"Yoo","sequence":"first","affiliation":[{"name":"Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada 1"},{"name":"Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole L.","family":"Galligan","sequence":"additional","affiliation":[{"name":"Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada 1"},{"name":"Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Virtanen","sequence":"additional","affiliation":[{"name":"Microarray Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor N.","family":"Fish","sequence":"additional","affiliation":[{"name":"Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada 1"},{"name":"Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada 2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2010,6,14]]},"reference":[{"key":"2023072917561503100_bib1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.immuni.2007.05.021","article-title":"Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch","volume":"27","author":"Amsen","year":"2007","journal-title":"Immunity."},{"key":"2023072917561503100_bib2","first-page":"31","article-title":"Coxsackie B viruses and human heart disease","volume":"223","author":"Baboonian","year":"1997","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2023072917561503100_bib3","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"2023072917561503100_bib4","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.4049\/jimmunol.168.11.5507","article-title":"Id2 negatively regulates B cell differentiation in the spleen","volume":"168","author":"Becker-Herman","year":"2002","journal-title":"J. Immunol."},{"key":"2023072917561503100_bib5","doi-asserted-by":"publisher","first-page":"8670","DOI":"10.1073\/pnas.0402644101","article-title":"Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus","volume":"101","author":"Belz","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072917561503100_bib6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1038\/ni1505","article-title":"Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells","volume":"8","author":"Belz","year":"2007","journal-title":"Nat. Immunol."},{"key":"2023072917561503100_bib7","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.4049\/jimmunol.177.5.3260","article-title":"Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation","volume":"177","author":"Blasius","year":"2006","journal-title":"J. Immunol."},{"key":"2023072917561503100_bib8","doi-asserted-by":"crossref","first-page":"6760","DOI":"10.4049\/jimmunol.180.10.6760","article-title":"Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220\u2212BST-2+ leukocyte population","volume":"180","author":"Br\u00e9hin","year":"2008","journal-title":"J. Immunol."},{"key":"2023072917561503100_bib9","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1080\/01926230701302558","article-title":"Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A\/PR\/8\/34 in C57BL\/6 mice","volume":"35","author":"Buchweitz","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"2023072917561503100_bib10","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1084\/jem.177.2.475","article-title":"Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia","volume":"177","author":"Carding","year":"1993","journal-title":"J. Exp. Med."},{"key":"2023072917561503100_bib11","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/79747","article-title":"Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization","volume":"1","author":"Cella","year":"2000","journal-title":"Nat. Immunol."},{"key":"2023072917561503100_bib12","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.virol.2005.06.023","article-title":"Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infection","volume":"340","author":"Chapman","year":"2005","journal-title":"Virology."},{"key":"2023072917561503100_bib13","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1189\/jlb.0106024","article-title":"Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages","volume":"79","author":"Chelvarajan","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"2023072917561503100_bib14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1128\/jcm.24.1.157-160.1986","article-title":"Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus","volume":"24","author":"Clements","year":"1986","journal-title":"J. Clin. Microbiol."},{"key":"2023072917561503100_bib15","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.4049\/jimmunol.170.10.4926","article-title":"The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells","volume":"170","author":"Corcoran","year":"2003","journal-title":"J. Immunol."},{"key":"2023072917561503100_bib16","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1146\/annurev.med.51.1.407","article-title":"Global epidemiology of influenza: past and present","volume":"51","author":"Cox","year":"2000","journal-title":"Annu. Rev. Med."},{"key":"2023072917561503100_bib17","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0002-9440(10)65068-7","article-title":"Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus","volume":"156","author":"Dawson","year":"2000","journal-title":"Am. J. Pathol."},{"key":"2023072917561503100_bib18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1006\/smim.1993.1048","article-title":"Induction of immunoglobulin synthesis by CD4+ T cell clones","volume":"5","author":"DeKruyff","year":"1993","journal-title":"Semin. Immunol."},{"key":"2023072917561503100_bib19","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/ni1343","article-title":"Influenza and the challenge for immunology","volume":"7","author":"Doherty","year":"2006","journal-title":"Nat. Immunol."},{"key":"2023072917561503100_bib20","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.4049\/jimmunol.151.5.2399","article-title":"Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family","volume":"151","author":"Fleming","year":"1993","journal-title":"J. Immunol."},{"key":"2023072917561503100_bib21","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.immuni.2005.01.016","article-title":"Regulatory T cell lineage specification by the forkhead transcription factor foxp3","volume":"22","author":"Fontenot","year":"2005","journal-title":"Immunity."},{"key":"2023072917561503100_bib22","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S1074-7613(01)00243-6","article-title":"IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo","volume":"15","author":"Fort","year":"2001","journal-title":"Immunity."},{"key":"2023072917561503100_bib23","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0166-3542(90)90048-C","article-title":"Serum IgG subclass antibody responses in children vaccinated with influenza virus antigens by live attenuated or inactivated vaccines","volume":"14","author":"Garcon","year":"1990","journal-title":"Antiviral Res."},{"key":"2023072917561503100_bib24","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1084\/jem.20071365","article-title":"Clearance of influenza virus from the lung depends on migratory langerin+CD11b\u2212 but not plasmacytoid dendritic cells","volume":"205","author":"GeurtsvanKessel","year":"2008","journal-title":"J. Exp. Med."},{"key":"2023072917561503100_bib25","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1084\/jem.180.4.1273","article-title":"Influenza virus\u2013specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection","volume":"180","author":"Graham","year":"1994","journal-title":"J. Exp. Med."},{"key":"2023072917561503100_bib26","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/ni903","article-title":"Transcriptional profiling identifies Id2 function in dendritic cell development","volume":"4","author":"Hacker","year":"2003","journal-title":"Nat. Immunol."},{"key":"2023072917561503100_bib27","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4049\/jimmunol.169.1.443","article-title":"New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25","volume":"169","author":"Hurst","year":"2002","journal-title":"J. Immunol."},{"key":"2023072917561503100_bib28","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1002\/(SICI)1521-4141(199912)29:12&lt;4092::AID-IMMU4092&gt;3.0.CO;2-A","article-title":"The interplay between the duration of TCR and cytokine signaling determines T cell polarization","volume":"29","author":"Iezzi","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"2023072917561503100_bib29","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics."},{"key":"2023072917561503100_bib30","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1084\/jem.20051135","article-title":"TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand","volume":"202","author":"Ito","year":"2005","journal-title":"J. Exp. Med."},{"key":"2023072917561503100_bib31","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2023072917561503100_bib32","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1189\/jlb.68.2.180","article-title":"Influence of type 2 T cell responses on the severity of encephalitis associated with influenza virus infection","volume":"68","author":"Kaji","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"2023072917561503100_bib33","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1084\/jem.191.5.771","article-title":"Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15\u2013deficient mice","volume":"191","author":"Kennedy","year":"2000","journal-title":"J. Exp. Med."},{"key":"2023072917561503100_bib34","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/S0092-8674(00)80453-5","article-title":"Identification of clonogenic common lymphoid progenitors in mouse bone marrow","volume":"91","author":"Kondo","year":"1997","journal-title":"Cell."},{"key":"2023072917561503100_bib35","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1146\/annurev.immunol.21.120601.141007","article-title":"Biology of hematopoietic stem cells and progenitors: implications for clinical application","volume":"21","author":"Kondo","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"2023072917561503100_bib36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.immuni.2007.07.005","article-title":"Notch: filling a hole in T helper 2 cell differentiation","volume":"27","author":"Kubo","year":"2007","journal-title":"Immunity."},{"key":"2023072917561503100_bib37","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/sj.icb.7100026","article-title":"A question of self-preservation: immunopathology in influenza virus infection","volume":"85","author":"La Gruta","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"2023072917561503100_bib38","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S1074-7613(03)00023-2","article-title":"Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection","volume":"18","author":"Legge","year":"2003","journal-title":"Immunity."},{"key":"2023072917561503100_bib39","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1126\/science.282.5390.941","article-title":"TNF-alpha induction of CD44-mediated leukocyte adhesion by sulfation","volume":"282","author":"Maiti","year":"1998","journal-title":"Science."},{"key":"2023072917561503100_bib40","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.4049\/jimmunol.163.9.4673","article-title":"TH cells primed during influenza virus infection provide help for qualitatively distinct antibody responses to subsequent immunization","volume":"163","author":"Marshall","year":"1999","journal-title":"J. Immunol."},{"key":"2023072917561503100_bib41","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1084\/jem.20080314","article-title":"Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs","volume":"205","author":"McGill","year":"2008","journal-title":"J. Exp. Med."},{"key":"2023072917561503100_bib42","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1182\/blood.V95.11.3489","article-title":"Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells","volume":"95","author":"McKenna","year":"2000","journal-title":"Blood."},{"key":"2023072917561503100_bib43","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature."},{"key":"2023072917561503100_bib44","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/ni1522","article-title":"Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo","volume":"8","author":"Naik","year":"2007","journal-title":"Nat. Immunol."},{"key":"2023072917561503100_bib45","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.4049\/jimmunol.158.3.1108","article-title":"Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells","volume":"158","author":"Oliver","year":"1997","journal-title":"J. Immunol."},{"key":"2023072917561503100_bib46","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1128\/jvi.69.4.2075-2081.1995","article-title":"Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice","volume":"69","author":"Palladino","year":"1995","journal-title":"J. Virol."},{"key":"2023072917561503100_bib47","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.4049\/jimmunol.173.3.1978","article-title":"Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract","volume":"173","author":"Renegar","year":"2004","journal-title":"J. Immunol."},{"key":"2023072917561503100_bib48","doi-asserted-by":"publisher","first-page":"R17","DOI":"10.1186\/gb-2008-9-1-r17","article-title":"Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling","volume":"9","author":"Robbins","year":"2008","journal-title":"Genome Biol."},{"key":"2023072917561503100_bib49","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/00062752-199905000-00007","article-title":"Interleukin-5 and the regulation of eosinophil production","volume":"6","author":"Roboz","year":"1999","journal-title":"Curr. Opin. Hematol."},{"key":"2023072917561503100_bib50","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0167-5699(97)80019-9","article-title":"The TH1\/TH2 paradigm","volume":"18","author":"Romagnani","year":"1997","journal-title":"Immunol. Today."},{"key":"2023072917561503100_bib51","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/0167-5699(91)90063-Y","article-title":"The role of T-cell subsets and cytokines in the regulation of infection","volume":"12","author":"Scott","year":"1991","journal-title":"Immunol. Today."},{"key":"2023072917561503100_bib52","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.virusres.2004.08.015","article-title":"The exit of vaccinia virus from infected cells","volume":"106","author":"Smith","year":"2004","journal-title":"Virus Res."},{"key":"2023072917561503100_bib53","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/ni.1738","article-title":"Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response","volume":"10","author":"Sokol","year":"2009","journal-title":"Nat. Immunol."},{"key":"2023072917561503100_bib54","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nm.1929","article-title":"Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10","volume":"15","author":"Sun","year":"2009","journal-title":"Nat. Med."},{"key":"2023072917561503100_bib55","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1159\/000079649","article-title":"Bronchocentric granulomatosis associated with influenza-A virus infection","volume":"71","author":"van der Klooster","year":"2004","journal-title":"Respiration."},{"key":"2023072917561503100_bib56","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1189\/jlb.1203644","article-title":"Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in mice","volume":"76","author":"Wareing","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"2023072917561503100_bib57","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1749-6632.1996.tb21115.x","article-title":"The role of Th1 and Th2 cells for mucosal IgA responses","volume":"778","author":"Yamamoto","year":"1996","journal-title":"Ann. NY Acad. Sci."},{"key":"2023072917561503100_bib58","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1532\/IJH97.04164","article-title":"Migration of dendritic cells","volume":"81","author":"Yoneyama","year":"2005","journal-title":"Int. J. Hematol."},{"key":"2023072917561503100_bib59","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4049\/jimmunol.179.1.391","article-title":"Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection","volume":"179","author":"Yoon","year":"2007","journal-title":"J. Immunol."},{"key":"2023072917561503100_bib60","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S0092-8674(00)80240-8","article-title":"The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells","volume":"89","author":"Zheng","year":"1997","journal-title":"Cell."},{"key":"2023072917561503100_bib61","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/ni1360","article-title":"Thymic stromal lymphopoietin in normal and pathogenic T cell development and function","volume":"7","author":"Ziegler","year":"2006","journal-title":"Nat. Immunol."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/207\/7\/1435\/1904000\/jem_20091373.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/207\/7\/1435\/1904000\/jem_20091373.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T17:57:11Z","timestamp":1690653431000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/207\/7\/1435\/53835\/Identification-of-a-novel-antigen-presenting-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,14]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7,5]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20091373","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6,14]]}}}