{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:03:59Z","timestamp":1785243839988,"version":"3.55.0"},"reference-count":69,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,10,26]]},"abstract":"<jats:p>The eye is protected by the ocular immunosurveillance system. We show that tear duct\u2013associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding\/differentiation 2, retinoic acid\u2013related orphan receptor \u03b3t, lymphotoxin (LT) \u03b11\u03b22\u2013LT\u03b2R, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity.<\/jats:p>","DOI":"10.1084\/jem.20091436","type":"journal-article","created":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T01:12:08Z","timestamp":1255396328000},"page":"2351-2364","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":69,"title":["Id2-, ROR\u03b3t-, and LT\u03b2R-independent initiation of lymphoid organogenesis in ocular immunity"],"prefix":"10.1084","volume":"206","author":[{"given":"Takahiro","family":"Nagatake","sequence":"first","affiliation":[{"name":"Division of Mucosal Immunology, Department of Microbiology and Immunology 1 , 2 , 3 , and 4"},{"name":"Medical Proteomics Laboratory 1 , 2 , 3 , and 4"},{"name":"Division of Bacterial Infection, Department of Microbiology and Immunology 1 , 2 , 3 , and 4"},{"name":"Division of Cellular and Molecular Biology, The Institute 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