{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:49:05Z","timestamp":1792550945946,"version":"4.5.0"},"reference-count":36,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,5,10]]},"abstract":"<jats:p>Batf belongs to the activator protein 1 superfamily of basic leucine zipper transcription factors that includes Fos, Jun, and Atf proteins. Batf is expressed in mouse T and B lymphocytes, although the importance of Batf to the function of these lineages has not been fully investigated. We generated mice (Batf\u0394Z\/\u0394Z) in which Batf protein is not produced. Batf\u0394Z\/\u0394Z mice contain normal numbers of B cells but show reduced numbers of peripheral CD4+ T cells. Analysis of CD4+ T helper (Th) cell subsets in Batf\u0394Z\/\u0394Z mice demonstrated that Batf is required for the development of functional Th type 17 (Th17), Th2, and follicular Th (Tfh) cells. In response to antigen immunization, germinal centers were absent in Batf\u0394Z\/\u0394Z mice and the maturation of Ig-secreting B cells was impaired. Although adoptive transfer experiments confirmed that this B cell phenotype can be driven by defects in the Batf\u0394Z\/\u0394Z CD4+ T cell compartment, stimulation of Batf\u0394Z\/\u0394Z B cells in vitro, or by a T cell\u2013independent antigen in vivo, resulted in proliferation but not class-switch recombination. We conclude that loss of Batf disrupts multiple components of the lymphocyte communication network that are required for a robust immune response.<\/jats:p>","DOI":"10.1084\/jem.20091548","type":"journal-article","created":{"date-parts":[[2010,4,27]],"date-time":"2010-04-27T02:18:47Z","timestamp":1272334727000},"page":"933-942","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":233,"title":["Batf coordinates multiple aspects of B and T cell function required for normal antibody responses"],"prefix":"10.1084","volume":"207","author":[{"given":"Briana C.","family":"Betz","sequence":"first","affiliation":[{"name":"Department of Biological Sciences 1 , 2 and 3"},{"name":"Department of Comparative Pathobiology 1 , 2 and 3"},{"name":"Purdue University Center for Cancer Research, Purdue University West Lafayette, IN 47907 1 , 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly L.","family":"Jordan-Williams","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences 1 , 2 and 3"},{"name":"Department of Comparative Pathobiology 1 , 2 and 3"},{"name":"Purdue University Center for Cancer Research, Purdue University West Lafayette, IN 47907 1 , 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences 1 , 2 and 3"},{"name":"Department of Comparative Pathobiology 1 , 2 and 3"},{"name":"Purdue University Center for Cancer Research, Purdue University West Lafayette, IN 47907 1 , 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Goo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences 1 , 2 and 3"},{"name":"Department of Comparative Pathobiology 1 , 2 and 3"},{"name":"Purdue University Center for Cancer Research, Purdue University West Lafayette, IN 47907 1 , 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences 1 , 2 and 3"},{"name":"Department of Comparative Pathobiology 1 , 2 and 3"},{"name":"Purdue University Center for Cancer Research, Purdue University West Lafayette, IN 47907 1 , 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Logan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences 1 , 2 and 3"},{"name":"Department of Comparative Pathobiology 1 , 2 and 3"},{"name":"Purdue University Center for Cancer Research, Purdue University West Lafayette, IN 47907 1 , 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences 1 , 2 and 3"},{"name":"Department of Comparative Pathobiology 1 , 2 and 3"},{"name":"Purdue University Center for Cancer Research, Purdue University West Lafayette, IN 47907 1 , 2 and 3"},{"name":"Department of Biological Sciences 1 , 2 and 3"},{"name":"Department of Comparative Pathobiology 1 , 2 and 3"},{"name":"Purdue University Center for Cancer Research, Purdue University West Lafayette, IN 47907 1 , 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Taparowsky","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences 1 , 2 and 3"},{"name":"Department of Comparative Pathobiology 1 , 2 and 3"},{"name":"Purdue University Center for Cancer Research, Purdue University West Lafayette, IN 47907 1 , 2 and 3"},{"name":"Department of Biological Sciences 1 , 2 and 3"},{"name":"Department of Comparative Pathobiology 1 , 2 and 3"},{"name":"Purdue University Center for Cancer Research, Purdue University West Lafayette, IN 47907 1 , 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,4,26]]},"reference":[{"key":"2023072522032889700_bib1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/1471-2164-7-107","article-title":"Reduction\/oxidation-phosphorylation control of DNA binding in the bZIP dimerization network","volume":"7","author":"Amoutzias","year":"2006","journal-title":"BMC Genomics."},{"key":"2023072522032889700_bib2","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1128\/MCB.17.6.3094","article-title":"Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions","volume":"17","author":"Aronheim","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"2023072522032889700_bib3","first-page":"2255","article-title":"B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family","volume":"11","author":"Dorsey","year":"1995","journal-title":"Oncogene."},{"key":"2023072522032889700_bib4","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1038\/sj.onc.1203491","article-title":"B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos","volume":"19","author":"Echlin","year":"2000","journal-title":"Oncogene."},{"key":"2023072522032889700_bib5","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nrc1209","article-title":"AP-1: a double-edged sword in tumorigenesis","volume":"3","author":"Eferl","year":"2003","journal-title":"Nat. Rev. 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