{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:47:28Z","timestamp":1792540048835,"version":"4.5.0"},"reference-count":31,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,3,15]]},"abstract":"<jats:p>Mast cell production of interleukin-10 (IL-10) can limit the skin pathology induced by chronic low-dose ultraviolet (UV)-B irradiation. Although the mechanism that promotes mast cell IL-10 production in this setting is unknown, exposure of the skin to UVB irradiation induces increased production of the immune modifying agent 1\u03b1,25-dihydroxyvitamin D3 (1\u03b1,25[OH]2D3). We now show that 1\u03b1,25(OH)2D3 can up-regulate IL-10 mRNA expression and induce IL-10 secretion in mouse mast cells in vitro. To investigate the roles of 1\u03b1,25(OH)2D3 and mast cell vitamin D receptor (VDR) expression in chronically UVB-irradiated skin in vivo, we engrafted the skin of genetically mast cell\u2013deficient WBB6F1-KitW\/W-v mice with bone marrow\u2013derived cultured mast cells derived from C57BL\/6 wild-type or VDR\u2212\/\u2212 mice. Optimal mast cell\u2013dependent suppression of the inflammation, local production of proinflammatory cytokines, epidermal hyperplasia, and epidermal ulceration associated with chronic UVB irradiation of the skin in KitW\/W-v mice required expression of VDR by the adoptively transferred mast cells. Our findings suggest that 1\u03b1,25(OH)2D3\/VDR-dependent induction of IL-10 production by cutaneous mast cells can contribute to the mast cell\u2019s ability to suppress inflammation and skin pathology at sites of chronic UVB irradiation.<\/jats:p>","DOI":"10.1084\/jem.20091725","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T23:41:01Z","timestamp":1267486861000},"page":"455-463","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":100,"title":["Evidence that vitamin D3 promotes mast cell\u2013dependent reduction of chronic UVB-induced skin pathology in mice"],"prefix":"10.1084","volume":"207","author":[{"given":"Lisa","family":"Biggs","sequence":"first","affiliation":[{"name":"Division of Human Immunology, Centre for Cancer Biology, Adelaide 5000, South Australia, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunping","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Human Immunology, Centre for Cancer Biology, Adelaide 5000, South Australia, Australia 1"},{"name":"Schools of Molecular and Biomedical Sciences or Medicine, University of Adelaide, Adelaide 5000, South Australia, Australia 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Fedoric","sequence":"additional","affiliation":[{"name":"Division of Human Immunology, Centre for Cancer Biology, Adelaide 5000, South Australia, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel F.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Division of Human Immunology, Centre for Cancer Biology, Adelaide 5000, South Australia, Australia 1"},{"name":"Schools of Molecular and Biomedical Sciences or Medicine, University of Adelaide, Adelaide 5000, South Australia, Australia 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele A.","family":"Grimbaldeston","sequence":"additional","affiliation":[{"name":"Division of Human Immunology, Centre for Cancer Biology, Adelaide 5000, South Australia, Australia 1"},{"name":"Schools of Molecular and Biomedical Sciences or Medicine, University of Adelaide, Adelaide 5000, South Australia, Australia 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,3,1]]},"reference":[{"key":"2023072917422035100_bib1","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1046\/j.1523-1747.1999.00772.x","article-title":"Local ultraviolet B irradiation impairs contact hypersensitivity induction by triggering release of tumor necrosis factor-alpha from mast cells. 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