{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:11:37Z","timestamp":1792174297903,"version":"4.4.0"},"reference-count":42,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,2,15]]},"abstract":"<jats:p>Production of type I interferon (IFN; IFN-\u03b1\u03b2) increases host susceptibility to Listeria monocytogenes, whereas type II IFN (IFN-\u03b3) activates macrophages to resist infection. We show that these opposing immunological effects of IFN-\u03b1\u03b2 and IFN-\u03b3 occur because of cross talk between the respective signaling pathways. We found that cultured macrophages infected with L. monocytogenes were refractory to IFN-\u03b3 treatment as a result of down-regulation of the IFN-\u03b3 receptor (IFNGR). The soluble factor responsible for these effects was identified as host IFN-\u03b1\u03b2. Accordingly, macrophages and dendritic cells (DCs) showed reduced IFNGR1 expression and reduced responsiveness to IFN-\u03b3 during systemic infection of IFN-\u03b1\u03b2\u2013responsive mice. Furthermore, the increased resistance of mice lacking the IFN-\u03b1\u03b2 receptor (IFNAR\u2212\/\u2212) to L. monocytogenes correlated with increased expression of IFN-\u03b3\u2013dependent activation markers by macrophages and DCs and was reversed by depletion of IFN-\u03b3. Thus, IFN-\u03b1\u03b2 produced in response to bacterial infection and other stimuli antagonizes the host response to IFN-\u03b3 by down-regulating the IFNGR. Such cross talk permits prioritization of IFN-\u03b1\u03b2\u2013type immune responses and may contribute to the beneficial effects of IFN-\u03b2 in treatment of inflammatory diseases such as multiple sclerosis.<\/jats:p>","DOI":"10.1084\/jem.20091746","type":"journal-article","created":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T22:05:48Z","timestamp":1265061948000},"page":"327-337","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":197,"title":["Induction of IFN-\u03b1\u03b2 enables\n                    <i>Listeria monocytogenes<\/i>\n                    to suppress macrophage activation by IFN-\u03b3"],"prefix":"10.1084","volume":"207","author":[{"given":"Manira","family":"Rayamajhi","sequence":"first","affiliation":[{"name":"National Jewish Health, Denver, CO 80206 1"},{"name":"Integrated Department of Immunology, University of Colorado, Denver, Denver, CO 80206 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Humann","sequence":"additional","affiliation":[{"name":"National Jewish Health, Denver, CO 80206 1"},{"name":"Integrated Department of Immunology, University of Colorado, Denver, Denver, CO 80206 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Penheiter","sequence":"additional","affiliation":[{"name":"National Jewish Health, Denver, CO 80206 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Andreasen","sequence":"additional","affiliation":[{"name":"National Jewish Health, Denver, CO 80206 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel L.","family":"Lenz","sequence":"additional","affiliation":[{"name":"National Jewish Health, Denver, CO 80206 1"},{"name":"Integrated Department of Immunology, University of Colorado, Denver, Denver, CO 80206 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,2,1]]},"reference":[{"key":"2023072917431215700_bib1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1084\/jem.20040976","article-title":"Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes","volume":"200","author":"Auerbuch","year":"2004","journal-title":"J. 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