{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:40:45Z","timestamp":1791268845053,"version":"4.1.0"},"reference-count":44,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,4,12]]},"abstract":"<jats:p>Controlling osteoclastogenesis is critical to maintain physiological bone homeostasis and prevent skeletal disorders. Although signaling activating nuclear factor of activated T cells 1 (NFATc1), a transcription factor essential for osteoclastogenesis, has been intensively investigated, factors antagonistic to NFATc1 in osteoclasts have not been characterized. Here, we describe a novel pathway that maintains bone homeostasis via two transcriptional repressors, B cell lymphoma 6 (Bcl6) and B lymphocyte\u2013induced maturation protein-1 (Blimp1). We show that Bcl6 directly targets \u2018osteoclastic\u2019 molecules such as NFATc1, cathepsin K, and dendritic cell-specific transmembrane protein (DC-STAMP), all of which are targets of NFATc1. Bcl6-overexpression inhibited osteoclastogenesis in vitro, whereas Bcl6-deficient mice showed accelerated osteoclast differentiation and severe osteoporosis. We report that Bcl6 is a direct target of Blimp1 and that mice lacking Blimp1 in osteoclasts exhibit osteopetrosis caused by impaired osteoclastogenesis resulting from Bcl6 up-regulation. Indeed, mice doubly mutant in Blimp1 and Bcl6 in osteoclasts exhibited decreased bone mass with increased osteoclastogenesis relative to osteoclast-specific Blimp1-deficient mice. These results reveal a Blimp1\u2013Bcl6\u2013osteoclastic molecule axis, which critically regulates bone homeostasis by controlling osteoclastogenesis and may provide a molecular basis for novel therapeutic strategies.<\/jats:p>","DOI":"10.1084\/jem.20091957","type":"journal-article","created":{"date-parts":[[2010,4,5]],"date-time":"2010-04-05T20:47:12Z","timestamp":1270500432000},"page":"751-762","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":184,"title":["The Blimp1\u2013Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis"],"prefix":"10.1084","volume":"207","author":[{"given":"Yoshiteru","family":"Miyauchi","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Kato","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Bioscience, University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tokuhisa","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitinori","family":"Saitou","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Toyama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Suda","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"},{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"},{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5"},{"name":"Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology 1 , 2 , 3 , 4 , 5"},{"name":"Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5"},{"name":"Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan 9"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,4,5]]},"reference":[{"key":"2023072920341842100_bib1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/36593","article-title":"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function","volume":"390","author":"Anderson","year":"1997","journal-title":"Nature."},{"key":"2023072920341842100_bib2","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1084\/jem.20051150","article-title":"Autoamplification of NFATc1 expression determines its essential role in bone homeostasis","volume":"202","author":"Asagiri","year":"2005","journal-title":"J. Exp. Med."},{"key":"2023072920341842100_bib3","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1073\/pnas.042702599","article-title":"The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis","volume":"99","author":"Baron","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072920341842100_bib4","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.4049\/jimmunol.181.4.2338","article-title":"Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression","volume":"181","author":"Cimmino","year":"2008","journal-title":"J. Immunol."},{"key":"2023072920341842100_bib5","doi-asserted-by":"publisher","first-page":"13823","DOI":"10.1073\/pnas.95.23.13823","article-title":"T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6","volume":"95","author":"Dent","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072920341842100_bib6","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1101\/gad.13.18.2412","article-title":"RANK is essential for osteoclast and lymph node development","volume":"13","author":"Dougall","year":"1999","journal-title":"Genes Dev."},{"key":"2023072920341842100_bib7","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1084\/jem.186.3.439","article-title":"Disruption of the Bcl6 gene results in an impaired germinal center formation","volume":"186","author":"Fukuda","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023072920341842100_bib8","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4049\/jimmunol.173.2.883","article-title":"Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells","volume":"173","author":"Ichii","year":"2004","journal-title":"J. Immunol."},{"key":"2023072920341842100_bib9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.bbrc.2004.10.024","article-title":"Dimer formation of receptor activator of nuclear factor kappa B induces incomplete osteoclast formation","volume":"325","author":"Iwamoto","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023072920341842100_bib10","first-page":"3149","article-title":"The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice","volume":"119","author":"Iwasawa","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2023072920341842100_bib11","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.yexcr.2008.11.015","article-title":"Blimp1: a conserved transcriptional repressor critical for differentiation of many tissues","volume":"315","author":"John","year":"2009","journal-title":"Exp. Cell Res."},{"key":"2023072920341842100_bib12","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/ni1321","article-title":"Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance","volume":"7","author":"Kallies","year":"2006","journal-title":"Nat. Immunol."},{"key":"2023072920341842100_bib13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S1534-5807(02)00157-0","article-title":"Reaching a genetic and molecular understanding of skeletal development","volume":"2","author":"Karsenty","year":"2002","journal-title":"Dev. Cell."},{"key":"2023072920341842100_bib14","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1101\/gad.5.5.868","article-title":"Identification and characterization of a novel repressor of beta-interferon gene expression","volume":"5","author":"Keller","year":"1991","journal-title":"Genes Dev."},{"key":"2023072920341842100_bib15","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1182\/blood-2006-09-048249","article-title":"MafB negatively regulates RANKL-mediated osteoclast differentiation","volume":"109","author":"Kim","year":"2007","journal-title":"Blood."},{"key":"2023072920341842100_bib16","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nature02444","article-title":"Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis","volume":"428","author":"Koga","year":"2004","journal-title":"Nature."},{"key":"2023072920341842100_bib17","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nm1270","article-title":"NFAT and Osterix cooperatively regulate bone formation","volume":"11","author":"Koga","year":"2005","journal-title":"Nat. Med."},{"key":"2023072920341842100_bib18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong","year":"1999","journal-title":"Nature."},{"key":"2023072920341842100_bib19","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1101\/gad.1649908","article-title":"Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice","volume":"22","author":"Kurimoto","year":"2008","journal-title":"Genes Dev."},{"key":"2023072920341842100_bib20","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.4049\/jimmunol.170.5.2435","article-title":"Inhibition of Th2 differentiation and GATA-3 expression by BCL-6","volume":"170","author":"Kusam","year":"2003","journal-title":"J. Immunol."},{"key":"2023072920341842100_bib21","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1182\/blood-2005-07-2798","article-title":"Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation","volume":"107","author":"Lee","year":"2006","journal-title":"Blood."},{"key":"2023072920341842100_bib22","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1359\/jbmr.060313","article-title":"Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass","volume":"21","author":"Li","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"2023072920341842100_bib23","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/ni1320","article-title":"Transcriptional repressor Blimp-1 regulates T cell homeostasis and function","volume":"7","author":"Martins","year":"2006","journal-title":"Nat. Immunol."},{"key":"2023072920341842100_bib24","doi-asserted-by":"publisher","first-page":"45969","DOI":"10.1074\/jbc.M408795200","article-title":"Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1","volume":"279","author":"Matsumoto","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2023072920341842100_bib25","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1182\/blood.V96.13.4335","article-title":"An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor kappa B ligand","volume":"96","author":"Miyamoto","year":"2000","journal-title":"Blood."},{"key":"2023072920341842100_bib26","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.cell.2007.07.025","article-title":"Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts","volume":"130","author":"Nakamura","year":"2007","journal-title":"Cell."},{"key":"2023072920341842100_bib27","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.abb.2008.04.004","article-title":"The dynamic interplay between osteoclasts and the immune system","volume":"473","author":"Nakashima","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"2023072920341842100_bib28","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/ng1321","article-title":"Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR","volume":"36","author":"Ng","year":"2004","journal-title":"Nat. Genet."},{"key":"2023072920341842100_bib29","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/369497a0","article-title":"NF-AT components define a family of transcription factors targeted in T-cell activation","volume":"369","author":"Northrop","year":"1994","journal-title":"Nature."},{"key":"2023072920341842100_bib30","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature03813","article-title":"Blimp1 is a critical determinant of the germ cell lineage in mice","volume":"436","author":"Ohinata","year":"2005","journal-title":"Nature."},{"key":"2023072920341842100_bib31","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.cell.2009.03.014","article-title":"A signaling principle for the specification of the germ cell lineage in mice","volume":"137","author":"Ohinata","year":"2009","journal-title":"Cell."},{"key":"2023072920341842100_bib32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3960\/jslrt.46.43","article-title":"Pathogenetic and clinical implications of non-immunoglobulin; BCL6 translocations in B-cell non-Hodgkin\u2019s lymphoma","volume":"46","author":"Ohno","year":"2006","journal-title":"J. Clin. Exp. Hematop."},{"key":"2023072920341842100_bib33","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1126\/science.289.5484.1508","article-title":"Therapeutic approaches to bone diseases","volume":"289","author":"Rodan","year":"2000","journal-title":"Science."},{"key":"2023072920341842100_bib34","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/nm1515","article-title":"Regulation of osteoclast differentiation and function by the CaMK-CREB pathway","volume":"12","author":"Sato","year":"2006","journal-title":"Nat. Med."},{"key":"2023072920341842100_bib35","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1093\/intimm\/dxn082","article-title":"The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function","volume":"20","author":"Sawatani","year":"2008","journal-title":"Int. Immunol."},{"key":"2023072920341842100_bib36","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S1074-7613(02)00335-7","article-title":"Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program","volume":"17","author":"Shaffer","year":"2002","journal-title":"Immunity."},{"key":"2023072920341842100_bib37","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/nri1572","article-title":"Regulation of plasma-cell development","volume":"5","author":"Shapiro-Shelef","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"2023072920341842100_bib38","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.cell.2007.12.037","article-title":"Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals","volume":"132","author":"Shinohara","year":"2008","journal-title":"Cell."},{"key":"2023072920341842100_bib39","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell."},{"key":"2023072920341842100_bib40","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0092-8674(94)90321-2","article-title":"Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells","volume":"77","author":"Turner","year":"1994","journal-title":"Cell."},{"key":"2023072920341842100_bib41","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1242\/dev.01711","article-title":"The zinc finger transcriptional repressor Blimp1\/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse","volume":"132","author":"Vincent","year":"2005","journal-title":"Development."},{"key":"2023072920341842100_bib42","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1084\/jem.20050645","article-title":"DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells","volume":"202","author":"Yagi","year":"2005","journal-title":"J. Exp. Med."},{"key":"2023072920341842100_bib43","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1359\/jbmr.070401","article-title":"Induction of DC-STAMP by alternative activation and downstream signaling mechanisms","volume":"22","author":"Yagi","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"2023072920341842100_bib44","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1038\/nm.2007","article-title":"Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis","volume":"15","author":"Zhao","year":"2009","journal-title":"Nat. Med."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/207\/4\/751\/1911463\/jem_20091957.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/207\/4\/751\/1911463\/jem_20091957.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T16:34:48Z","timestamp":1690648488000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/207\/4\/751\/40707\/The-Blimp1-Bcl6-axis-is-critical-to-regulate"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,5]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4,12]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20091957","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3264957.2951056","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.3264957.3523067","asserted-by":"object"}]},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4,5]]}}}