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Two genes with critical roles in TCR signaling were deregulated in Bcl11b-deficient CD8+ T cells, CD8 coreceptor and Plc\u03b31, both of which may contribute to the impaired responsiveness. Bcl11b was found to bind the E8I, E8IV, and E8V, but not E8II or E8III, enhancers. Thus, Bcl11b is one of the transcription factors implicated in the maintenance of optimal CD8 coreceptor expression in peripheral CD8+ T cells through association with specific enhancers. Short-lived Klrg1hiCD127lo effector CD8+ T cells were formed during the course of infection in the absence of Bcl11b, albeit in smaller numbers, and their Ag-specific cytolytic activity on a per-cell basis was altered, which was associated with reduced granzyme B and perforin.<\/jats:p>","DOI":"10.1084\/jem.20092136","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T23:17:55Z","timestamp":1280186275000},"page":"1687-1699","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b"],"prefix":"10.1084","volume":"207","author":[{"given":"Shuning","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Rozell","sequence":"additional","affiliation":[{"name":"Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj K.","family":"Verma","sequence":"additional","affiliation":[{"name":"Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana I.","family":"Albu","sequence":"additional","affiliation":[{"name":"Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Califano","sequence":"additional","affiliation":[{"name":"Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"VanValkenburgh","sequence":"additional","affiliation":[{"name":"Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akeel","family":"Merchant","sequence":"additional","affiliation":[{"name":"Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rangel-Moreno","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy D.","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, Proteos, Singapore 138673 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal G.","family":"Copeland","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, Proteos, Singapore 138673 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pentao","family":"Liu","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, England, UK 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Avram","sequence":"additional","affiliation":[{"name":"Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,7,26]]},"reference":[{"key":"2023072522181741400_bib1","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1084\/jem.20070863","article-title":"BCL11B is required for positive selection and survival of double-positive thymocytes","volume":"204","author":"Albu","year":"2007","journal-title":"J. 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