{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:36:36Z","timestamp":1792100196446,"version":"4.4.0"},"reference-count":67,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,6,7]]},"abstract":"<jats:p>The characterization of human dendritic cell (DC) subsets is essential for the design of new vaccines. We report the first detailed functional analysis of the human CD141+ DC subset. CD141+ DCs are found in human lymph nodes, bone marrow, tonsil, and blood, and the latter proved to be the best source of highly purified cells for functional analysis. They are characterized by high expression of toll-like receptor 3, production of IL-12p70 and IFN-\u03b2, and superior capacity to induce T helper 1 cell responses, when compared with the more commonly studied CD1c+ DC subset. Polyinosine-polycytidylic acid (poly I:C)\u2013activated CD141+ DCs have a superior capacity to cross-present soluble protein antigen (Ag) to CD8+ cytotoxic T lymphocytes than poly I:C\u2013activated CD1c+ DCs. Importantly, CD141+ DCs, but not CD1c+ DCs, were endowed with the capacity to cross-present viral Ag after their uptake of necrotic virus-infected cells. These findings establish the CD141+ DC subset as an important functionally distinct human DC subtype with characteristics similar to those of the mouse CD8\u03b1+ DC subset. The data demonstrate a role for CD141+ DCs in the induction of cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens.<\/jats:p>","DOI":"10.1084\/jem.20092140","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T23:25:35Z","timestamp":1274138735000},"page":"1247-1260","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":979,"title":["Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens"],"prefix":"10.1084","volume":"207","author":[{"given":"Sarah L.","family":"Jongbloed","sequence":"first","affiliation":[{"name":"Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Kassianos","sequence":"additional","affiliation":[{"name":"Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia 1"},{"name":"University of Queensland Faculty of Health Sciences, Herston, Queensland 4029, Australia 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie J.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina J.","family":"Clark","sequence":"additional","affiliation":[{"name":"Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia 1"},{"name":"University of Queensland Faculty of Health Sciences, Herston, Queensland 4029, Australia 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsheng","family":"Ju","sequence":"additional","affiliation":[{"name":"Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Angel","sequence":"additional","affiliation":[{"name":"School of Biological Sciences 3 and 4"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1142, New Zealand 3 and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Jen J.","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biological Sciences 3 and 4"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1142, New Zealand 3 and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Rod","family":"Dunbar","sequence":"additional","affiliation":[{"name":"School of Biological Sciences 3 and 4"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1142, New Zealand 3 and 4"},{"name":"School of Biological Sciences 3 and 4"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1142, New Zealand 3 and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Wadley","sequence":"additional","affiliation":[{"name":"Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varinder","family":"Jeet","sequence":"additional","affiliation":[{"name":"Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelie J.E.","family":"Vulink","sequence":"additional","affiliation":[{"name":"Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek N.J.","family":"Hart","sequence":"additional","affiliation":[{"name":"Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia 1"},{"name":"University of Queensland Faculty of Health Sciences, Herston, Queensland 4029, Australia 2"},{"name":"Cooperative Research Centre for Biomarker Translation, La Trobe University, Bundoora, Victoria 3086, Australia 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen J.","family":"Radford","sequence":"additional","affiliation":[{"name":"Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia 1"},{"name":"University of Queensland Faculty of Health Sciences, Herston, Queensland 4029, Australia 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,5,17]]},"reference":[{"key":"2023072522220329800_bib1","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.micinf.2008.07.038","article-title":"Can type-1 responses against intracellular pathogens be T helper 2 cytokine dependent?","volume":"10","author":"Alexander","year":"2008","journal-title":"Microbes Infect."},{"key":"2023072522220329800_bib2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1182\/blood-2002-04-1088","article-title":"Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells","volume":"101","author":"Aliberti","year":"2003","journal-title":"Blood."},{"key":"2023072522220329800_bib3","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1182\/blood-2008-06-165266","article-title":"Distinctive localization of antigen-presenting cells in human lymph nodes","volume":"113","author":"Angel","year":"2009","journal-title":"Blood."},{"key":"2023072522220329800_bib4","doi-asserted-by":"publisher","first-page":"10018","DOI":"10.1128\/JVI.74.21.10018-10024.2000","article-title":"Incoming human cytomegalovirus pp65 (UL83) contained in apoptotic infected fibroblasts is cross-presented to CD8(+) T cells by dendritic cells","volume":"74","author":"Arrode","year":"2000","journal-title":"J. Virol."},{"key":"2023072522220329800_bib5","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.4049\/jimmunol.0802286","article-title":"Characterization of an immediate splenic precursor of CD8+ dendritic cells capable of inducing antiviral T cell responses","volume":"182","author":"Bedoui","year":"2009","journal-title":"J. Immunol."},{"key":"2023072522220329800_bib6","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/ni.1724","article-title":"Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells","volume":"10","author":"Bedoui","year":"2009","journal-title":"Nat. Immunol."},{"key":"2023072522220329800_bib7","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1084\/jem.20032220","article-title":"In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination","volume":"199","author":"Bonifaz","year":"2004","journal-title":"J. Exp. Med."},{"key":"2023072522220329800_bib8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.coi.2007.12.002","article-title":"Endocytosis mechanisms and the cell biology of antigen presentation","volume":"20","author":"Burgdorf","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"2023072522220329800_bib9","doi-asserted-by":"publisher","first-page":"3264","DOI":"10.1182\/blood-2008-05-155176","article-title":"The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement","volume":"112","author":"Caminschi","year":"2008","journal-title":"Blood."},{"key":"2023072522220329800_bib10","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1084\/jem.20081370","article-title":"TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events","volume":"205","author":"Cavassani","year":"2008","journal-title":"J. Exp. Med."},{"key":"2023072522220329800_bib11","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1084\/jem.192.12.1685","article-title":"CD8+ but not CD8\u2212 dendritic cells cross-prime cytotoxic T cells in vivo","volume":"192","author":"den Haan","year":"2000","journal-title":"J. Exp. Med."},{"key":"2023072522220329800_bib12","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1016\/j.molimm.2008.03.012","article-title":"Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction","volume":"45","author":"Dong","year":"2008","journal-title":"Mol. Immunol."},{"key":"2023072522220329800_bib13","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1126\/science.1136080","article-title":"Differential antigen processing by dendritic cell subsets in vivo","volume":"315","author":"Dudziak","year":"2007","journal-title":"Science."},{"key":"2023072522220329800_bib14","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.4049\/jimmunol.165.11.6037","article-title":"BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood","volume":"165","author":"Dzionek","year":"2000","journal-title":"J. Immunol."},{"key":"2023072522220329800_bib15","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1002\/eji.200323797","article-title":"Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines","volume":"33","author":"Edwards","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"2023072522220329800_bib16","doi-asserted-by":"publisher","first-page":"21955","DOI":"10.1074\/jbc.M502095200","article-title":"Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule","volume":"280","author":"Galibert","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2023072522220329800_bib17","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1182\/blood.V90.9.3245","article-title":"Dendritic cells: unique leukocyte populations which control the primary immune response","volume":"90","author":"Hart","year":"1997","journal-title":"Blood."},{"key":"2023072522220329800_bib18","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science."},{"key":"2023072522220329800_bib19","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.4049\/jimmunol.166.9.5448","article-title":"Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets","volume":"166","author":"Hochrein","year":"2001","journal-title":"J. Immunol."},{"key":"2023072522220329800_bib20","doi-asserted-by":"publisher","first-page":"16693","DOI":"10.1074\/jbc.M709923200","article-title":"CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes","volume":"283","author":"Huysamen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2023072522220329800_bib21","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1084\/jem.20020161","article-title":"The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo","volume":"195","author":"Iyoda","year":"2002","journal-title":"J. Exp. Med."},{"key":"2023072522220329800_bib22","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1182\/blood-2002-12-3854","article-title":"Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: differential regulation of function by specific classes of physiologic stimuli","volume":"102","author":"Jefford","year":"2003","journal-title":"Blood."},{"key":"2023072522220329800_bib23","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1084\/jem.194.6.863","article-title":"Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens","volume":"194","author":"Kadowaki","year":"2001","journal-title":"J. Exp. Med."},{"key":"2023072522220329800_bib24","doi-asserted-by":"publisher","first-page":"12542","DOI":"10.1074\/jbc.M310175200","article-title":"mRNA is an endogenous ligand for Toll-like receptor 3","volume":"279","author":"Karik\u00f3","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2023072522220329800_bib25","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4049\/jimmunol.0901540","article-title":"Cutting edge: limited specialization of dendritic cell subsets for MHC class II-associated presentation of viral particles","volume":"184","author":"Keller","year":"2010","journal-title":"J. Immunol."},{"key":"2023072522220329800_bib26","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1007\/s00262-009-0670-2","article-title":"Unconventional cytokine profiles and development of T cell memory in long-term survivors after cancer vaccination","volume":"58","author":"Kyte","year":"2009","journal-title":"Cancer Immunol. Immunother."},{"key":"2023072522220329800_bib27","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4049\/jimmunol.177.1.372","article-title":"Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells","volume":"177","author":"Lahoud","year":"2006","journal-title":"J. Immunol."},{"key":"2023072522220329800_bib28","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cytogfr.2007.10.007","article-title":"Type I interferon as a stimulus for cross-priming","volume":"19","author":"Le Bon","year":"2008","journal-title":"Cytokine Growth Factor Rev."},{"key":"2023072522220329800_bib29","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1002\/eji.200838155","article-title":"CXCL10\/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy","volume":"38","author":"Lindell","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"2023072522220329800_bib30","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.4049\/jimmunol.175.8.4839","article-title":"Gene family clustering identifies functionally associated subsets of human in vivo blood and tonsillar dendritic cells","volume":"175","author":"Lindstedt","year":"2005","journal-title":"J. Immunol."},{"key":"2023072522220329800_bib31","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.immuni.2008.08.008","article-title":"In vivo induction of immune responses to pathogens by conventional dendritic cells","volume":"29","author":"L\u00f3pez-Bravo","year":"2008","journal-title":"Immunity."},{"key":"2023072522220329800_bib32","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.immuni.2010.01.013","article-title":"Quantitative proteomics reveals subset-specific viral recognition in dendritic cells","volume":"32","author":"Luber","year":"2010","journal-title":"Immunity."},{"key":"2023072522220329800_bib33","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1182\/blood-2001-12-0360","article-title":"Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets","volume":"100","author":"Luft","year":"2002","journal-title":"Blood."},{"key":"2023072522220329800_bib34","doi-asserted-by":"publisher","first-page":"14509","DOI":"10.1073\/pnas.0806727105","article-title":"Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells","volume":"105","author":"Lundie","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072522220329800_bib35","doi-asserted-by":"publisher","first-page":"4512","DOI":"10.1182\/blood-2001-11-0097","article-title":"Characterization of human blood dendritic cell subsets","volume":"100","author":"MacDonald","year":"2002","journal-title":"Blood."},{"key":"2023072522220329800_bib36","doi-asserted-by":"publisher","first-page":"5934","DOI":"10.1158\/0008-5472.CAN-04-1261","article-title":"alpha-type-1 polarized dendritic cells: a novel immunization tool with optimized CTL-inducing activity","volume":"64","author":"Mailliard","year":"2004","journal-title":"Cancer Res."},{"key":"2023072522220329800_bib37","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1084\/jem.189.3.587","article-title":"CD8\u03b1+ and CD8\u03b1\u2212 subclasses of dendritic cells direct the development of distinct T helper cells in vivo","volume":"189","author":"Maldonado-L\u00f3pez","year":"1999","journal-title":"J. Exp. Med."},{"key":"2023072522220329800_bib38","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.4049\/jimmunol.171.6.3154","article-title":"Subcellular localization of Toll-like receptor 3 in human dendritic cells","volume":"171","author":"Matsumoto","year":"2003","journal-title":"J. Immunol."},{"key":"2023072522220329800_bib39","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/icb.2008.28","article-title":"Demystifying the development of dendritic cell subtypes, a little","volume":"86","author":"Naik","year":"2008","journal-title":"Immunol. Cell Biol."},{"key":"2023072522220329800_bib40","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.smim.2009.05.001","article-title":"RIG-I-like receptors: sensing and responding to RNA virus infection","volume":"21","author":"Nakhaei","year":"2009","journal-title":"Semin. Immunol."},{"key":"2023072522220329800_bib41","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1182\/blood-2002-03-0974","article-title":"Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors","volume":"101","author":"O\u2019Keeffe","year":"2003","journal-title":"Blood."},{"key":"2023072522220329800_bib42","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1182\/blood-2005-10-4077","article-title":"Toward the identification of a tolerogenic signature in IDO-competent dendritic cells","volume":"107","author":"Orabona","year":"2006","journal-title":"Blood."},{"key":"2023072522220329800_bib43","doi-asserted-by":"publisher","first-page":"5371","DOI":"10.1182\/blood-2006-08-038422","article-title":"Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets","volume":"109","author":"Piccioli","year":"2007","journal-title":"Blood."},{"key":"2023072522220329800_bib44","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/ni.1824","article-title":"Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production","volume":"11","author":"Poeck","year":"2010","journal-title":"Nat. Immunol."},{"key":"2023072522220329800_bib45","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.4049\/jimmunol.166.9.5327","article-title":"Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8- dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells","volume":"166","author":"Pooley","year":"2001","journal-title":"J. Immunol."},{"key":"2023072522220329800_bib46","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1073\/pnas.96.3.1036","article-title":"Distinct dendritic cell subsets differentially regulate the class of immune response in vivo","volume":"96","author":"Pulendran","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072522220329800_bib47","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1097\/01.cji.0000211310.90621.5d","article-title":"CD11c+ blood dendritic cells induce antigen-specific cytotoxic T lymphocytes with similar efficiency compared to monocyte-derived dendritic cells despite higher levels of MHC class I expression","volume":"29","author":"Radford","year":"2006","journal-title":"J. Immunother."},{"key":"2023072522220329800_bib48","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1084\/jem.186.11.1819","article-title":"In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas","volume":"186","author":"Reis e Sousa","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023072522220329800_bib49","doi-asserted-by":"publisher","first-page":"R17","DOI":"10.1186\/gb-2008-9-1-r17","article-title":"Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling","volume":"9","author":"Robbins","year":"2008","journal-title":"Genome Biol."},{"key":"2023072522220329800_bib50","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1128\/JVI.79.6.3350-3357.2005","article-title":"Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression","volume":"79","author":"Rudd","year":"2005","journal-title":"J. Virol."},{"key":"2023072522220329800_bib51","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1172\/JCI34584","article-title":"Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin","volume":"118","author":"Sancho","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2023072522220329800_bib52","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/nature07750","article-title":"Identification of a dendritic cell receptor that couples sensing of necrosis to immunity","volume":"458","author":"Sancho","year":"2009","journal-title":"Nature."},{"key":"2023072522220329800_bib53","doi-asserted-by":"publisher","first-page":"20416","DOI":"10.1073\/pnas.0808537105","article-title":"Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo","volume":"105","author":"Scheu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072522220329800_bib54","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1084\/jem.20021263","article-title":"ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8\u03b1+ dendritic cells","volume":"196","author":"Schiavoni","year":"2002","journal-title":"J. Exp. Med."},{"key":"2023072522220329800_bib55","doi-asserted-by":"publisher","first-page":"10729","DOI":"10.1073\/pnas.0601956103","article-title":"The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture","volume":"103","author":"Schnorrer","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072522220329800_bib56","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1182\/blood-2004-08-3105","article-title":"Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery","volume":"105","author":"Schnurr","year":"2005","journal-title":"Blood."},{"key":"2023072522220329800_bib57","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/nature03326","article-title":"Toll-like receptor 3 promotes cross-priming to virus-infected cells","volume":"433","author":"Schulz","year":"2005","journal-title":"Nature."},{"key":"2023072522220329800_bib58","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/nri746","article-title":"Mouse and human dendritic cell subtypes","volume":"2","author":"Shortman","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2023072522220329800_bib59","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1084\/jem.20062305","article-title":"CD8\u2212 DCs induce IL-12\u2013independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS","volume":"204","author":"Skokos","year":"2007","journal-title":"J. Exp. Med."},{"key":"2023072522220329800_bib60","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1084\/jem.20070176","article-title":"A subset of dendritic cells induces CD4+ T cells to produce IFN-\u03b3 by an IL-12\u2013independent but CD70-dependent mechanism in vivo","volume":"204","author":"Soares","year":"2007","journal-title":"J. Exp. Med."},{"key":"2023072522220329800_bib61","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.immuni.2008.08.001","article-title":"Dendritic cells in vivo: a key target for a new vaccine science","volume":"29","author":"Steinman","year":"2008","journal-title":"Immunity."},{"key":"2023072522220329800_bib62","doi-asserted-by":"publisher","first-page":"7783","DOI":"10.1073\/pnas.0509307103","article-title":"Langerhans cells cross-present antigen derived from skin","volume":"103","author":"Stoitzner","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072522220329800_bib63","doi-asserted-by":"publisher","first-page":"6700","DOI":"10.1128\/IAI.00861-06","article-title":"The frequency of BDCA3-positive dendritic cells is increased in the peripheral circulation of Kenyan children with severe malaria","volume":"74","author":"Urban","year":"2006","journal-title":"Infect. Immun."},{"key":"2023072522220329800_bib64","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1365-2249.2008.03734.x","article-title":"Human spleen contains different subsets of dendritic cells and regulatory T lymphocytes","volume":"154","author":"Vel\u00e1squez-Lopera","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"2023072522220329800_bib65","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nri2103","article-title":"Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo","volume":"7","author":"Villadangos","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2023072522220329800_bib66","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/S0065-230X(07)99006-5","article-title":"Dendritic cells in cancer immunotherapy","volume":"99","author":"Vulink","year":"2008","journal-title":"Adv. Cancer Res."},{"key":"2023072522220329800_bib67","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1128\/jvi.70.11.7569-7579.1996","article-title":"The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL","volume":"70","author":"Wills","year":"1996","journal-title":"J. Virol."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/207\/6\/1247\/1739113\/jem_20092140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/207\/6\/1247\/1739113\/jem_20092140.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T18:22:48Z","timestamp":1690309368000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/207\/6\/1247\/40924\/Human-CD141-BDCA-3-dendritic-cells-DCs-represent-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,17]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6,7]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20092140","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5,17]]}}}