{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:07:28Z","timestamp":1791281248846,"version":"4.1.0"},"reference-count":48,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,9,27]]},"abstract":"<jats:p>Regulatory T cells (T reg cells) constitute a population of CD4+ T cells that limits immune responses. The transcription factor Foxp3 is important for determining the development and function of T reg cells; however, the molecular mechanisms that trigger and maintain its expression remain incompletely understood. In this study, we show that mice deficient for the Ets-1 transcription factor (Ets-1\u2212\/\u2212) developed T cell\u2013mediated splenomegaly and systemic autoimmunity that can be blocked by functional wild-type T reg cells. Spleens of Ets-1\u2212\/\u2212 mice contained mostly activated T cells, including Th2-polarized CD4+ cells and had reduced percentages of T reg cells. Splenic and thymic Ets-1\u2212\/\u2212 T reg cells expressed low levels of Foxp3 and displayed the CD103 marker that characterizes antigen-experienced T reg cells. Thymic development of Ets-1\u2212\/\u2212 T reg cells appeared intrinsically altered as Foxp3-expressing cells differentiate poorly in mixed fetal liver reconstituted chimera and fetal thymic organ culture. Ets-1\u2212\/\u2212 T reg cells showed decreased in vitro suppression activity and did not protect Rag2\u2212\/\u2212 hosts from naive T cell\u2013induced inflammatory bowel disease. Furthermore, in T reg cells, Ets-1 interacted with the Foxp3 intronic enhancer and was required for demethylation of this regulatory sequence. These data demonstrate that Ets-1 is required for the development of natural T reg cells and suggest a role for this transcription factor in the regulation of Foxp3 expression.<\/jats:p>","DOI":"10.1084\/jem.20092153","type":"journal-article","created":{"date-parts":[[2010,9,21]],"date-time":"2010-09-21T04:10:53Z","timestamp":1285042253000},"page":"2113-2125","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":118,"title":["The Ets-1 transcription factor controls the development and function of natural regulatory T cells"],"prefix":"10.1084","volume":"207","author":[{"given":"Enguerran","family":"Mouly","sequence":"first","affiliation":[{"name":"EA3963, Universit\u00e9 Paris 7 Denis Diderot, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1 and 2"},{"name":"INSERM Administration D\u00e9l\u00e9gu\u00e9e R\u00e9gionale Paris Nord, Institut F\u00e9d\u00e9ratif de Recherche 105, Institut Universitaire d'H\u00e9matologie, 75475 Paris, France 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Chemin","sequence":"additional","affiliation":[{"name":"EA3963, Universit\u00e9 Paris 7 Denis Diderot, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1 and 2"},{"name":"INSERM Administration D\u00e9l\u00e9gu\u00e9e R\u00e9gionale Paris Nord, Institut F\u00e9d\u00e9ratif de Recherche 105, Institut Universitaire d'H\u00e9matologie, 75475 Paris, France 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Vu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"EA3963, Universit\u00e9 Paris 7 Denis Diderot, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1 and 2"},{"name":"INSERM Administration D\u00e9l\u00e9gu\u00e9e R\u00e9gionale Paris Nord, Institut F\u00e9d\u00e9ratif de Recherche 105, Institut Universitaire d'H\u00e9matologie, 75475 Paris, France 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Chopin","sequence":"additional","affiliation":[{"name":"EA3963, Universit\u00e9 Paris 7 Denis Diderot, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1 and 2"},{"name":"INSERM Administration D\u00e9l\u00e9gu\u00e9e R\u00e9gionale Paris Nord, Institut F\u00e9d\u00e9ratif de Recherche 105, Institut Universitaire d'H\u00e9matologie, 75475 Paris, France 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Mesnard","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche S 702, H\u00f4pital Tenon, Universit\u00e9 Pierre et Marie Curie Paris 6, 75970 Paris, France 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Leite-de-Moraes","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 8147, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris 5, 75743 Paris, France 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Burlen-defranoux","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 668, D\u00e9veloppement des Lymphocytes, Institut Pasteur, 75015 Paris, France 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bandeira","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 668, D\u00e9veloppement des Lymphocytes, Institut Pasteur, 75015 Paris, France 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Bories","sequence":"additional","affiliation":[{"name":"EA3963, Universit\u00e9 Paris 7 Denis Diderot, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1 and 2"},{"name":"INSERM Administration D\u00e9l\u00e9gu\u00e9e R\u00e9gionale Paris Nord, Institut F\u00e9d\u00e9ratif de Recherche 105, Institut Universitaire d'H\u00e9matologie, 75475 Paris, France 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,9,20]]},"reference":[{"key":"2023072521503876300_bib1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/ni1444","article-title":"Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells","volume":"8","author":"Aschenbrenner","year":"2007","journal-title":"Nat. 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