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Similarly, in a model of inflammation-induced corneal neovascularization, young TSP-1\u2013deficient mice develop exacerbated lymphangiogenesis, which can be reversed by topical application of recombinant human TSP-1. Such increased corneal lymphangiogenesis is also detected in mice lacking CD36, a receptor for TSP-1. In these mice, repopulation of corneal macrophages with predominantly WT mice via bone marrow reconstitution ameliorates their prolymphangiogenic phenotype. In vitro, exposure of WT macrophages to TSP-1 suppresses expression of lymphangiogenic factors vascular endothelial growth factor (VEGF)-C and VEGF-D, but not of a primarily hemangiogenic factor VEGF-A. Inhibition of VEGF-C is not detected in the absence or blockade of CD36. These findings suggest that TSP-1, by ligating CD36 on monocytic cells, acts as an endogenous inhibitor of lymphangiogenesis.<\/jats:p>","DOI":"10.1084\/jem.20092277","type":"journal-article","created":{"date-parts":[[2011,5,2]],"date-time":"2011-05-02T23:06:17Z","timestamp":1304377577000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":148,"title":["Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes"],"prefix":"10.1084","volume":"208","author":[{"given":"Claus","family":"Cursiefen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany 1"},{"name":"The Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02467 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuichi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"The Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02467 2"},{"name":"Kyoto Prefectural University School of Medicine, Kyoto 602-8566, Japan 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bock","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany 1"},{"name":"The Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02467 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Saban","sequence":"additional","affiliation":[{"name":"The Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02467 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Sadrai","sequence":"additional","affiliation":[{"name":"The Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02467 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Lawler","sequence":"additional","affiliation":[{"name":"Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Dana","sequence":"additional","affiliation":[{"name":"The Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02467 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Masli","sequence":"additional","affiliation":[{"name":"The Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02467 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2011,5,2]]},"reference":[{"key":"2023072600370704400_bib1","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/nm.2018","article-title":"Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth","volume":"15","author":"Albuquerque","year":"2009","journal-title":"Nat. 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