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These defects are restored by pretreatment with LPS and alum in an NLRP3- and ASC-dependent manner. Whereas pretreatment of wild-type mice with P2X7 antagonists, the ATP-degrading enzyme apyrase or IL-1 receptor antagonist, prevents CHS, IL-1\u03b2 injection restores CHS in P2X7-deficient mice. Thus, P2X7 is a crucial receptor for extracellular ATP released in skin in response to contact allergens. The lack of P2X7 triggering prevents IL-1\u03b2 release, which is an essential step in the sensitization process. Interference with P2X7 signaling may be a promising strategy for the prevention of allergic contact dermatitis.<\/jats:p>","DOI":"10.1084\/jem.20092489","type":"journal-article","created":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T01:59:39Z","timestamp":1289267979000},"page":"2609-2619","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":197,"title":["Lack of the purinergic receptor P2X7 results in resistance to contact hypersensitivity"],"prefix":"10.1084","volume":"207","author":[{"given":"Felix C.","family":"Weber","sequence":"first","affiliation":[{"name":"Allergy Research Group, Department of Dermatology 1 , 2 , and 3"},{"name":"Chronic Obstructive Pulmonary Disease and Asthma Research Group, Department of Pneumology 1 , 2 , and 3"},{"name":"Department of Internal Medicine I, University Medical Center Freiburg, D-79104 Freiburg, Germany 1 , 2 , and 3"},{"name":"Faculty of Biology, University of Freiburg, D-79104 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