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Gnaq\u2212\/\u2212 chimeric mice rapidly develop arthritis as well as other manifestations of systemic autoimmune disease. Importantly, we demonstrate that the development of the autoreactive B cell compartment is the result of an intrinsic defect in Gnaq\u2212\/\u2212 B cells, resulting in the aberrant activation of the prosurvival factor Akt. Together, these data show for the first time that signaling through trimeric G proteins is critically important for maintaining control of peripheral B cell tolerance induction and repressing autoimmunity.<\/jats:p>","DOI":"10.1084\/jem.20092735","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T03:00:12Z","timestamp":1278990012000},"page":"1775-1789","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["G\u03b1q-containing G proteins regulate B cell selection and survival and are required to prevent B cell\u2013dependent autoimmunity"],"prefix":"10.1084","volume":"207","author":[{"given":"Ravi S.","family":"Misra","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY 14642 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