{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:01:32Z","timestamp":1790913692768,"version":"4.1.0"},"reference-count":39,"publisher":"Rockefeller University Press","issue":"7","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,7,5]]},"abstract":"<jats:p>A recessive mutation named Justy was found that abolishes B lymphopoiesis but does not impair other major aspects of hematopoiesis. Transplantation experiments showed that homozygosity for Justy prevented hematopoietic progenitors from generating B cells but did not affect the ability of bone marrow stroma to support B lymphopoiesis. In bone marrow from mutant mice, common lymphoid progenitors and pre-pro\u2013B cells appeared normal, but cells at subsequent stages of B lymphopoiesis were dramatically reduced in number. Under culture conditions that promoted B lymphopoiesis, mutant pre-pro\u2013B cells remained alive and began expressing the B cell marker CD19 but failed to proliferate. In contrast, these cells were able to generate myeloid or T\/NK precursors. Genetic and molecular analysis demonstrated that Justy is a point mutation within the Gon4-like (Gon4l) gene, which encodes a protein with homology to transcriptional regulators. This mutation was found to disrupt Gon4l pre-mRNA splicing and dramatically reduce expression of wild-type Gon4l RNA and protein. Consistent with a role for Gon4l in transcriptional regulation, the levels of RNA encoding C\/EBP\u03b1 and PU.1 were abnormally high in mutant B cell progenitors. Our findings indicate that the Gon4l protein is required for B lymphopoiesis and may function to regulate gene expression during this process.<\/jats:p>","DOI":"10.1084\/jem.20100147","type":"journal-article","created":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T04:15:37Z","timestamp":1275970537000},"page":"1359-1367","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["The <i>Justy<\/i> mutation identifies <i>Gon4-like<\/i> as a gene that is essential for B lymphopoiesis"],"prefix":"10.1084","volume":"207","author":[{"given":"Ping","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine 1 , 2 , 3 , and 4"},{"name":"Department of Anatomy and Cell Biology 1 , 2 , 3 , and 4"},{"name":"Department of Pathology 1 , 2 , 3 , and 4"},{"name":"the Immunology Graduate Program, Roy J. and Lucille A. 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