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Instead, the primary reason for the loss of resistance results from a decreased number of total and mature natural killer (NK) cells in the blood and an intrinsic impairment in their ability to migrate to the lymph node draining the site of infection, which is essential to curb systemic virus spread. Hence, our work links the age-dependent increase in susceptibility to a viral disease to a specific defect of NK cells, opening the possibility of exploring treatments to improve NK cell function in the aged with the goal of enhancing their resistance to viral diseases.<\/jats:p>","DOI":"10.1084\/jem.20100282","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T00:24:38Z","timestamp":1285633478000},"page":"2369-2381","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":106,"title":["Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking"],"prefix":"10.1084","volume":"207","author":[{"given":"Min","family":"Fang","sequence":"first","affiliation":[{"name":"Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Roscoe","sequence":"additional","affiliation":[{"name":"Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis J.","family":"Sigal","sequence":"additional","affiliation":[{"name":"Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,9,27]]},"reference":[{"key":"2023072521560191500_bib1","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.4049\/jimmunol.168.11.5403","article-title":"Inhibitory effects of cytomegalovirus proteins US2 and US11 point to contributions from direct priming and cross-priming in induction of vaccinia virus-specific CD8(+) T cells","volume":"168","author":"Basta","year":"2002","journal-title":"J. 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