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This novel pathway of antigen acquisition was detectable when FDCs were loaded with purified antigens bound into classical antigen\u2013antibody immune complexes, as well as after pregnancy, when they are loaded physiologically with antigens associated with the complement-fixed microparticles released from the placenta into maternal blood. In both cases, ensuing antigen presentation was profoundly tolerogenic, as it induced T cell deletion even under inflammatory conditions. These results significantly broaden the scope of FDC function and suggest new ways that the complement system and persistent antigen presentation might influence T cell activation and the maintenance of peripheral immune tolerance.<\/jats:p>","DOI":"10.1084\/jem.20100354","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T00:59:30Z","timestamp":1292893170000},"page":"135-148","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Acquisition and presentation of follicular dendritic cell\u2013bound antigen by lymph node\u2013resident dendritic cells"],"prefix":"10.1084","volume":"208","author":[{"given":"Megan L.","family":"McCloskey","sequence":"first","affiliation":[{"name":"Department of Pathology 1 , 2 , and 3"},{"name":"Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine 1 , 2 , and 3"},{"name":"New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Curotto de Lafaille","sequence":"additional","affiliation":[{"name":"Department of Pathology 1 , 2 , and 3"},{"name":"Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine 1 , 2 , and 3"},{"name":"New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1 , 2 , and 3"},{"name":"Department of Pathology 1 , 2 , and 3"},{"name":"Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine 1 , 2 , and 3"},{"name":"New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Program in Cellular and Molecular Medicine, Immune Disease Institute, Children\u2019s Hospital Boston, Harvard Medical School, Boston, MA 02115 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Erlebacher","sequence":"additional","affiliation":[{"name":"Department of Pathology 1 , 2 , and 3"},{"name":"Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine 1 , 2 , and 3"},{"name":"New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1 , 2 , and 3"},{"name":"Department of Pathology 1 , 2 , and 3"},{"name":"Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine 1 , 2 , and 3"},{"name":"New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,12,20]]},"reference":[{"key":"2023072522364171300_bib1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S1074-7613(00)80433-1","article-title":"Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen","volume":"4","author":"Ahearn","year":"1996","journal-title":"Immunity."},{"key":"2023072522364171300_bib2","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1084\/jem.20031591","article-title":"Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN","volume":"199","author":"Ahonen","year":"2004","journal-title":"J. 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