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In this study, we further investigate the properties of CD44v.low cells and show that they are significantly more efficient than the remaining naive (CD44low or CD44int) and memory CD4+ cell subsets in reconstituting the overall size of the CD4+ T cell pool, creating a T cell pool with a diverse TCR repertoire, generating regulatory T cells that express forkhead box P3 (FoxP3), and promoting homeostatic equilibrium between naive, memory, and Foxp3+ regulatory T cell numbers. T cell population reconstitution by CD44v.low cells is thymus independent. Compared with CD44int cells, a higher percentage of CD44v.low cells express B cell leukemia\/lymphoma 2, interleukin-7 receptor, and CD5. The data support a key role for CD4+ CD44v.low cells as peripheral precursors that maintain the integrity of the CD4+ T cell pool.<\/jats:p>","DOI":"10.1084\/jem.20100598","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T04:41:20Z","timestamp":1292301680000},"page":"2883-2894","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["A peripheral CD4+ T cell precursor for naive, memory, and regulatory T cells"],"prefix":"10.1084","volume":"207","author":[{"given":"Chunfang","family":"Zhao","sequence":"first","affiliation":[{"name":"Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna D.","family":"Davies","sequence":"additional","affiliation":[{"name":"Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,12,13]]},"reference":[{"key":"2023072617182809300_bib1","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1084\/jem.20040249","article-title":"In vivo instruction of suppressor commitment in naive T cells","volume":"199","author":"Apostolou","year":"2004","journal-title":"J. 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