{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:56:11Z","timestamp":1790690171480,"version":"4.1.0"},"reference-count":20,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,5,10]]},"abstract":"<jats:p>The nonreceptor tyrosine kinase SYK has recently received a good deal of attention as a critical oncogene in various hematologic malignancies. A newly developed model of peripheral T cell lymphoma (PTCL) using the ITK-SYK fusion gene should serve as a powerful tool to dissect the signaling cascades important for SYK-associated malignancy in the context of t(5;9) PTCL.<\/jats:p>","DOI":"10.1084\/jem.20100608","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T01:36:57Z","timestamp":1272937017000},"page":"911-913","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Peripheral T cell lymphoma: new model + new insight"],"prefix":"10.1084","volume":"207","author":[{"given":"James C.","family":"Mulloy","sequence":"first","affiliation":[{"name":"J.C. Mulloy is with the Division of Experimental Hematology and Cancer Biology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,5,3]]},"reference":[{"key":"2023072601371805800_bib1","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1038\/sj.leu.2403894","article-title":"Gatekeeper pathways and cellular background in the pathogenesis and therapy of AML","volume":"19","author":"Cammenga","year":"2005","journal-title":"Leukemia."},{"key":"2023072601371805800_bib2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1600-065X.1998.tb01238.x","article-title":"The Syk family of protein tyrosine kinases in T-cell activation and development","volume":"165","author":"Chu","year":"1998","journal-title":"Immunol. Rev."},{"key":"2023072601371805800_bib3","doi-asserted-by":"publisher","first-page":"S168","DOI":"10.3816\/CLM.2008.s.013","article-title":"Pathobiology of mature T-cell lymphomas","volume":"8","author":"Cotta","year":"2008","journal-title":"Clin. Lymphoma Myeloma."},{"key":"2023072601371805800_bib4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature08638","article-title":"Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma","volume":"463","author":"Davis","year":"2010","journal-title":"Nature."},{"key":"2023072601371805800_bib5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.critrevonc.2009.01.002","article-title":"Molecular classification of T-cell lymphomas","volume":"72","author":"de Leval","year":"2009","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"2023072601371805800_bib6","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ctrv.2009.12.004","article-title":"Exploiting cellular pathways to develop new treatment strategies for AML","volume":"36","author":"Fathi","year":"2010","journal-title":"Cancer Treat. Rev."},{"key":"2023072601371805800_bib7","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/leu.2008.77","article-title":"Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas","volume":"22","author":"Feldman","year":"2008","journal-title":"Leukemia."},{"key":"2023072601371805800_bib8","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1182\/blood-2009-08-236471","article-title":"Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia","volume":"115","author":"Friedberg","year":"2010","journal-title":"Blood."},{"key":"2023072601371805800_bib9","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ccr.2009.08.018","article-title":"Proteomic and genetic approaches identify Syk as an AML target","volume":"16","author":"Hahn","year":"2009","journal-title":"Cancer Cell."},{"key":"2023072601371805800_bib10","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/j.1600-065X.2008.00740.x","article-title":"Conformational snapshots of Tec kinases during signaling","volume":"228","author":"Joseph","year":"2009","journal-title":"Immunol. Rev."},{"key":"2023072601371805800_bib11","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrc1589","article-title":"Mechanisms of B-cell lymphoma pathogenesis","volume":"5","author":"K\u00fcppers","year":"2005","journal-title":"Nat. Rev. Cancer."},{"key":"2023072601371805800_bib12","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1084\/jem.20070405","article-title":"Distinct roles for Syk and ZAP-70 during early thymocyte development","volume":"204","author":"Palacios","year":"2007","journal-title":"J. Exp. Med."},{"key":"2023072601371805800_bib13","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1084\/jem.20092042","article-title":"The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma","volume":"207","author":"Pechloff","year":"2010","journal-title":"J. Exp. Med."},{"key":"2023072601371805800_bib14","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1172\/JCI26833","article-title":"Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targets","volume":"117","author":"Piccaluga","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2023072601371805800_bib15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1600-065X.2008.00746.x","article-title":"The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development","volume":"228","author":"Prince","year":"2009","journal-title":"Immunol. Rev."},{"key":"2023072601371805800_bib16","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.critrevonc.2008.10.011","article-title":"Current and future aggressive peripheral T-cell lymphoma treatment paradigms, biological features and therapeutic molecular targets","volume":"71","author":"Rodr\u00edguez","year":"2009","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"2023072601371805800_bib17","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/sj.leu.2404045","article-title":"Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma","volume":"20","author":"Streubel","year":"2006","journal-title":"Leukemia."},{"key":"2023072601371805800_bib18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0074-7696(04)36004-3","article-title":"Transgenic mice as an in vivo model of lymphomagenesis","volume":"236","author":"Tarantul","year":"2004","journal-title":"Int. Rev. Cytol."},{"key":"2023072601371805800_bib19","doi-asserted-by":"publisher","first-page":"32650","DOI":"10.1074\/jbc.M806340200","article-title":"Molecular mechanism of the Syk activation switch","volume":"283","author":"Tsang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2023072601371805800_bib20","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S0167-5699(99)01574-1","article-title":"Tyrosine kinase SYK: essential functions for immunoreceptor signalling","volume":"21","author":"Turner","year":"2000","journal-title":"Immunol. Today."}],"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/207\/5\/911\/1747197\/jem_20100608.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/207\/5\/911\/1747197\/jem_20100608.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T01:37:32Z","timestamp":1690335452000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/207\/5\/911\/40703\/Peripheral-T-cell-lymphoma-new-model-new"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,3]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5,10]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20100608","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5,3]]}}}