{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:04:01Z","timestamp":1791353041927,"version":"4.3.1"},"reference-count":30,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,9,27]]},"abstract":"<jats:p>Although dendritic cells (DCs) are adept initiators of CD4+ T cell responses, their fundamental importance in this regard in Th2 settings remains to be demonstrated. We have used CD11c\u2013diphtheria toxin (DTx) receptor mice to deplete CD11c+ cells during the priming stage of the CD4+ Th2 response against the parasitic helminth Schistosoma mansoni. DTx treatment significantly depleted CD11c+ DCs from all tissues tested, with 70\u201380% efficacy. Even this incomplete depletion resulted in dramatically impaired CD4+ T cell production of Th2 cytokines, altering the balance of the immune response and causing a shift toward IFN-\u03b3 production. In contrast, basophil depletion using Mar-1 antibody had no measurable effect on Th2 induction in this system. These data underline the vital role that CD11c+ antigen-presenting cells can play in orchestrating Th2 development against helminth infection in vivo, a response that is ordinarily balanced so as to prevent the potentially damaging production of inflammatory cytokines.<\/jats:p>","DOI":"10.1084\/jem.20100734","type":"journal-article","created":{"date-parts":[[2010,9,6]],"date-time":"2010-09-06T21:09:26Z","timestamp":1283807366000},"page":"2089-2096","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":251,"title":["CD11c depletion severely disrupts Th2 induction and development in vivo"],"prefix":"10.1084","volume":"207","author":[{"given":"Alexander T.","family":"Phythian-Adams","sequence":"first","affiliation":[{"name":"Institute of Immunology and Infection Research 1 and 2"},{"name":"Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Cook","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research 1 and 2"},{"name":"Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Lundie","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research 1 and 2"},{"name":"Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy H.","family":"Jones","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research 1 and 2"},{"name":"Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research 1 and 2"},{"name":"Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom A.","family":"Barr","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research 1 and 2"},{"name":"Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Hochweller","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, German Cancer Research Centre, 69120 Heidelberg, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Anderton","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research 1 and 2"},{"name":"Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter J.","family":"H\u00e4mmerling","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, German Cancer Research Centre, 69120 Heidelberg, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M.","family":"Maizels","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research 1 and 2"},{"name":"Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research 1 and 2"},{"name":"Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,9,6]]},"reference":[{"key":"2023072521551968800_bib1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature."},{"key":"2023072521551968800_bib2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.0105-2896.2009.00875.x","article-title":"Defining dendritic cells by conditional and constitutive cell ablation","volume":"234","author":"Bar-On","year":"2010","journal-title":"Immunol. 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