{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:04:11Z","timestamp":1787007851502,"version":"build-2736575974"},"reference-count":45,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:p>DAP12, an immunoreceptor tyrosine-based activation motif\u2013bearing adapter protein, is involved in innate immunity mediated by natural killer cells and myeloid cells. We show that DAP12-deficient mouse B cells and B cells from a patient with Nasu-Hakola disease, a recessive genetic disorder resulting from loss of DAP12, showed enhanced proliferation after stimulation with anti-IgM or CpG. Myeloid-associated immunoglobulin-like receptor (MAIR) II (Cd300d) is a DAP12-associated immune receptor. Like DAP12-deficient B cells, MAIR-II\u2013deficient B cells were hyperresponsive. Expression of a chimeric receptor composed of the MAIR-II extracellular domain directly coupled to DAP12 into the DAP12-deficient or MAIR-II\u2013deficient B cells suppressed B cell receptor (BCR)\u2013mediated proliferation. The chimeric MAIR-II\u2013DAP12 receptor recruited the SH2 domain\u2013containing protein tyrosine phosphatase 1 (SHP-1) after BCR stimulation. DAP12-deficient mice showed elevated serum antibodies against self-antigens and enhanced humoral immune responses against T cell\u2013dependent and T cell\u2013independent antigens. Thus, DAP12-coupled MAIR-II negatively regulates B cell\u2013mediated adaptive immune responses.<\/jats:p>","DOI":"10.1084\/jem.20101623","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T22:18:38Z","timestamp":1309817918000},"page":"1661-1671","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["The immunoreceptor adapter protein DAP12 suppresses B lymphocyte\u2013driven adaptive immune responses"],"prefix":"10.1084","volume":"208","author":[{"given":"Takako","family":"Nakano-Yokomizo","sequence":"first","affiliation":[{"name":"Department of Immunology, Institute of Basic Medical Sciences 1 , and 2 , 3"},{"name":"Department of Neurology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences 1 , and 2 , 3"},{"name":"Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), University of Tsukuba, Ibaraki 305-8575, 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