{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:55:09Z","timestamp":1791420909576,"version":"4.3.3"},"reference-count":51,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,8,29]]},"abstract":"<jats:p>Extracellular adenosine triphosphate (ATP) can activate purinergic receptors of the plasma membrane and modulate multiple cellular functions. We report that ATP is released from HIV-1 target cells through pannexin-1 channels upon interaction between the HIV-1 envelope protein and specific target cell receptors. Extracellular ATP then acts on purinergic receptors, including P2Y2, to activate proline-rich tyrosine kinase 2 (Pyk2) kinase and transient plasma membrane depolarization, which in turn stimulate fusion between Env-expressing membranes and membranes containing CD4 plus appropriate chemokine co-receptors. Inhibition of any of the constituents of this cascade (pannexin-1, ATP, P2Y2, and Pyk2) impairs the replication of HIV-1 mutant viruses that are resistant to conventional antiretroviral agents. Altogether, our results reveal a novel signaling pathway involved in the early steps of HIV-1 infection that may be targeted with new therapeutic approaches.<\/jats:p>","DOI":"10.1084\/jem.20101805","type":"journal-article","created":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T20:20:03Z","timestamp":1314044403000},"page":"1823-1834","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":169,"title":["Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection"],"prefix":"10.1084","volume":"208","author":[{"given":"Claire","family":"S\u00e9ror","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U848 1 and 2 , 3"},{"name":"Metabolomics Platform 1 and 2 , 3"},{"name":"Institut Gustave Roussy, F-94805 Villejuif, France 1 and 2 , 3"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U848 1 and 2 , 3"},{"name":"Metabolomics Platform 1 and 2 , 3"},{"name":"Institut Gustave Roussy, F-94805 Villejuif, France 1 and 2 , 3"},{"name":"Universit\u00e9 Paris Sud - 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