{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:22:49Z","timestamp":1791256969365,"version":"4.1.0"},"reference-count":34,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,10,24]]},"abstract":"<jats:p>Hematopoietic stem cells (HSCs) are maintained in a specific bone marrow (BM) niche in cavities formed by osteoclasts. Osteoclast-deficient mice are osteopetrotic and exhibit closed BM cavities. Osteoclast activity is inversely correlated with hematopoietic activity; however, how osteoclasts and the BM cavity potentially regulate hematopoiesis is not well understood. To investigate this question, we evaluated hematopoietic activity in three osteopetrotic mouse models: op\/op, c-Fos-deficient, and RANKL (receptor activator of nuclear factor kappa B ligand)-deficient mice. We show that, although osteoclasts and, by consequence, BM cavities are absent in these animals, hematopoietic stem and progenitor cell (HSPC) mobilization after granulocyte colony-stimulating factor injection was comparable or even higher in all three lines compared with wild-type mice. In contrast, osteoprotegerin-deficient mice, which have increased numbers of osteoclasts, showed reduced HSPC mobilization. BM-deficient patients and mice reportedly maintain hematopoiesis in extramedullary spaces, such as spleen; however, splenectomized op\/op mice did not show reduced HSPC mobilization. Interestingly, we detected an HSC population in osteopetrotic bone of op\/op mice, and pharmacological ablation of osteoclasts in wild-type mice did not inhibit, and even increased, HSPC mobilization. These results suggest that osteoclasts are dispensable for HSC mobilization and may function as negative regulators in the hematopoietic system.<\/jats:p>","DOI":"10.1084\/jem.20101890","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T04:51:02Z","timestamp":1318913462000},"page":"2175-2181","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":140,"title":["Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization"],"prefix":"10.1084","volume":"208","author":[{"given":"Kana","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuri","family":"Kawasumi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokuhiro","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , 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8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tami","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru 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, 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of 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Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru 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, and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisataka","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Bioindustry Division, Oriental Yeast Co., Itabashi-ku, Tokyo 174-8505, Japan 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef M.","family":"Penninger","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Toyama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Suda","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone Metabolism and Immunology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Pathology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Musculoskeletal Reconstruction and Regeneration Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Cell Differentiation, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Keio Kanrinmaru Project 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Dentistry and Oral Surgery 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Center for Human Metabolomic Systems Biology 1 , 2 , 3 , 4 , 5 , 6 , 7 , and 8"},{"name":"Department of Integrated Bone 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