{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:52:59Z","timestamp":1790758379138,"version":"4.1.0"},"reference-count":35,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,11,22]]},"abstract":"<jats:p>Graft-versus-host disease (GVHD) causes significant morbidity and mortality in allogeneic hematopoietic stem cell transplantation (aHSCT), preventing its broader application to non\u2013life-threatening diseases. We show that a single administration of a nondepleting monoclonal antibody specific for the coinhibitory immunoglobulin receptor, B and T lymphocyte associated (BTLA), permanently prevented GVHD when administered at the time of aHSCT. Once GVHD was established, anti-BTLA treatment was unable to reverse disease, suggesting that its mechanism occurs early after aHSCT. Anti-BTLA treatment prevented GVHD independently of its ligand, the costimulatory tumor necrosis factor receptor herpesvirus entry mediator (HVEM), and required BTLA expression by donor-derived T cells. Furthermore, anti-BTLA treatment led to the relative inhibition of CD4+ forkhead box P3\u2212 (Foxp3\u2212) effector T cell (T eff cell) expansion compared with precommitted naturally occurring donor-derived CD4+ Foxp3+ regulatory T cell (T reg cell) and allowed for graft-versus-tumor (GVT) effects as well as robust responses to pathogens. These results suggest that BTLA agonism rebalances T cell expansion in lymphopenic hosts after aHSCT, thereby preventing GVHD without global immunosuppression. Thus, targeting BTLA with a monoclonal antibody at the initiation of aHSCT therapy might reduce limitations imposed by histocompatibility and allow broader application to treatment of non\u2013life-threatening diseases.<\/jats:p>","DOI":"10.1084\/jem.20102017","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T00:58:00Z","timestamp":1289869080000},"page":"2551-2559","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":66,"title":["Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression"],"prefix":"10.1084","volume":"207","author":[{"given":"J\u00f6rn C.","family":"Albring","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology 1 , 2 , and 3"},{"name":"Howard Hughes Medical Institute 1 , 2 , and 3"},{"name":"Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St. 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