{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:01:27Z","timestamp":1792166487667,"version":"4.4.0"},"reference-count":31,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,5,9]]},"abstract":"<jats:p>De novo expression of Muc5ac, a mucin not normally expressed in the intestinal tract, is induced in the cecum of mice resistant to Trichuris muris infection. In this study, we investigated the role of Muc5ac, which is detected shortly before worm expulsion and is associated with the production of interleukin-13 (IL-13), in resistance to this nematode. Muc5ac-deficient mice were incapable of expelling T. muris from the intestine and harbored long-term chronic infections, despite developing strong TH2 responses. Muc5ac-deficient mice had elevated levels of IL-13 and, surprisingly, an increase in the TH1 cytokine IFN-\u03b3. Because TH1 inflammation is thought to favor chronic nematode infection, IFN-\u03b3 was neutralized in vivo, resulting in an even stronger TH2-type immune response. Nevertheless, despite a more robust TH2 effector response, the Muc5ac-deficient mice remained highly susceptible to chronic T. muris infection. Importantly, human MUC5AC had a direct detrimental effect on nematode vitality. Moreover, the absence of Muc5ac caused a significant delay in the expulsion of two other gut-dwelling nematodes (Trichinella spiralis and Nippostrongylus brasiliensis). Thus, for the first time, we identify a single mucin, Muc5ac, as a direct and critical mediator of resistance during intestinal nematode infection.<\/jats:p>","DOI":"10.1084\/jem.20102057","type":"journal-article","created":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T23:55:14Z","timestamp":1303170914000},"page":"893-900","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":270,"title":["Muc5ac: a critical component mediating the rejection of enteric nematodes"],"prefix":"10.1084","volume":"208","author":[{"given":"Sumaira Z.","family":"Hasnain","sequence":"first","affiliation":[{"name":"Wellcome Trust Centre for Cell Matrix Research 1 and 2"},{"name":"Manchester Immunology Group, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, England, UK 1 and 2"},{"name":"Wellcome Trust Centre for Cell Matrix Research 1 and 2"},{"name":"Manchester Immunology Group, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, England, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Matrix Research 1 and 2"},{"name":"Manchester Immunology Group, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, England, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen N.","family":"Kindrachuk","sequence":"additional","affiliation":[{"name":"Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Barron","sequence":"additional","affiliation":[{"name":"Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton F.","family":"Dickey","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Medical Research Council National Institutes for Medical Research, London NW7 1AA, England, UK 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Wynn","sequence":"additional","affiliation":[{"name":"Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Grencis","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Matrix Research 1 and 2"},{"name":"Manchester Immunology Group, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, England, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Thornton","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Cell Matrix Research 1 and 2"},{"name":"Manchester Immunology Group, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, England, UK 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2011,4,18]]},"reference":[{"key":"2023072600333824400_bib1","first-page":"4033","article-title":"Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance","volume":"7","author":"Andrianifahanana","year":"2001","journal-title":"Clin. 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