{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:14:40Z","timestamp":1791328480883,"version":"4.3.1"},"reference-count":30,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,5,9]]},"abstract":"<jats:p>Migratory skin dendritic cells (DCs) are thought to play an important role in priming T cell immune responses against Leishmania major, but DC subtypes responsible for the induction of protective immunity against this pathogen are still controversial. In this study, we analyzed the role of Langerin+ skin-derived DCs in the Leishmania model using inducible in vivo cell ablation. After physiologically relevant low-dose infection with L. major (1,000 parasites), mice depleted of all Langerin+ DCs developed significantly smaller ear lesions with decreased parasite loads and a reduced number of CD4+ Foxp3+ regulatory T cells (T reg cells) as compared with controls. This was accompanied by increased interferon \u03b3 production in lymph nodes in the absence of Langerin+ DCs. Moreover, selective depletion of Langerhans cells (LCs) demonstrated that the absence of LCs, and not Langerin+ dermal DC, was responsible for the reduced T reg cell immigration and the enhanced Th1 response, resulting in attenuated disease. Our data reveal a unique and novel suppressive role for epidermal LCs in L. major infection by driving the expansion of T reg cells. A better understanding of the various roles of different DC subsets in cutaneous leishmaniasis will improve the development of a potent therapeutic\/prophylactic vaccine.<\/jats:p>","DOI":"10.1084\/jem.20102318","type":"journal-article","created":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T03:06:17Z","timestamp":1304391977000},"page":"885-891","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":159,"title":["Langerhans cells are negative regulators of the anti-<i>Leishmania<\/i> response"],"prefix":"10.1084","volume":"208","author":[{"given":"Kordula","family":"Kautz-Neu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Johannes-Gutenberg University, 55131 Mainz, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelon","family":"Noordegraaf","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus MC, University Medical Center, 3015 GE Rotterdam, Netherlands 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Dinges","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johannes-Gutenberg University, 55131 Mainz, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare L.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Haematology, University College London, Royal Free Hospital, London NW3 2PF, England, UK 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"John","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johannes-Gutenberg University, 55131 Mainz, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn E.","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus MC, University Medical Center, 3015 GE Rotterdam, Netherlands 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"von Stebut","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johannes-Gutenberg University, 55131 Mainz, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2011,5,2]]},"reference":[{"key":"2023072602224517200_bib1","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.4049\/jimmunol.163.7.3890","article-title":"Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection","volume":"163","author":"Ahuja","year":"1999","journal-title":"J. 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